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Adam Resnick

Children’s Hospital of Philadelphia
Philadelphia, PA, USA

CBTN Specimen

84

CBTN Participants

109

CBTN Samples

Backer

NCI

About this

Project

High grade gliomas affect patients across age groups, and this project seeks to better understand high grade gliomas as they affect pediatric, adolescent, and young adult populations. The goal of this project is to generate single cell sequencing data of cancer cells, immune cells and non-immune microenvironment in pediatric and adolescent and young adult high-grade gliomas. Researchers hypothesize that combining analysis of single-cell techniques, the microenvironment, and the immune factors of tumors and matched preclinical models will lead to a better understanding of these diseases. Deeper understanding will then promote the development of more effective therapeutics to improve outcomes for patients. The Children's Brain Tumor Network provides a unique resource of samples and data necessary for this project.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Researchers will generate a map of tumor cells using single cell assays and conduct comprehensive analysis on high grade gliomas in order to generate data that will be integral to the development of new therapies.

What is the impact of this project?

This project takes a comprehensive approach that will lead to a much better understanding of high grade gliomas, how they differ across age groups, and what new therapeutic options should be pursued.

Why is the CBTN request important to this project?

The Children’s Brain Tumor Network will provide this project with rare pediatric tumor samples and data from the Pediatric Brain Tumor Atlas that is not accessible elsewhere.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing tissue samples.

Meet The

Team