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Adam Resnick

Children’s Hospital of Philadelphia
Philadelphia, PA, USA

CBTN Specimen

84

CBTN Participants

109

CBTN Samples

Backer

NCI

About this

Project

High grade gliomas affect patients across age groups, and this project seeks to better understand high grade gliomas as they affect pediatric, adolescent, and young adult populations. The goal of this project is to generate single cell sequencing data of cancer cells, immune cells and non-immune microenvironment in pediatric and adolescent and young adult high-grade gliomas. Researchers hypothesize that combining analysis of single-cell techniques, the microenvironment, and the immune factors of tumors and matched preclinical models will lead to a better understanding of these diseases. Deeper understanding will then promote the development of more effective therapeutics to improve outcomes for patients. The Children's Brain Tumor Network provides a unique resource of samples and data necessary for this project.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Researchers will generate a map of tumor cells using single cell assays and conduct comprehensive analysis on high grade gliomas in order to generate data that will be integral to the development of new therapies.

What is the impact of this project?

This project takes a comprehensive approach that will lead to a much better understanding of high grade gliomas, how they differ across age groups, and what new therapeutic options should be pursued.

Why is the CBTN request important to this project?

The Children’s Brain Tumor Network will provide this project with rare pediatric tumor samples and data from the Pediatric Brain Tumor Atlas that is not accessible elsewhere.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing tissue samples.

Meet The

Team

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Scientific Committee

Executive Board

Scientific co-Chair

Principal Investigator

Adam Resnick, PhD

Adam Resnick is the Director of Data Driven Discovery in Biomedicine (D3b) at Children’s Hospital of Philadelphia (CHOP) responsible for leading a multidisciplinary team to build and support a scalable, patient-focused healthcare and educational discovery ecosystem on behalf of all children. He is a

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Children’s Hospital of Philadelphia

Philadelphia, PA, USA
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Aaron Diaz, PhD

Cancer Biology & Cell SignalingDevelopmental & Stem Cell Biology

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UCSF Benioff Children's Hospital

San Francisco and Oakland, CA, USA
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Scientific Committee

Executive Board

Scientific co-Chair

Michael Prados, MD

Michael Prados began his career in Neuro-Oncology as a Fellow at the University of California San Francisco in 1985. Following a two year training program, he was recruited to the Faculty in 1988 and has remained at UCSF since that time, and holds the Charles B Wilson Chair in Neurosurgery. His care

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UCSF Benioff Children's Hospital

San Francisco and Oakland, CA, USA
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Scientific Committee

Executive Board

Principal Investigator

Michelle Monje, MD, PhD

Michelle Monje, MD, PhD joined the faculty at Stanford University in 2011 as an Assistant Professor of Neurology & Neurological Sciences. Following her undergraduate degree in biology at Vassar College, Dr. Monje received her MD and PhD in Neuroscience from Stanford University. She then completed ne

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Lucile Packard Children's Hospital Stanford

Palo Alto, CA, USA