Aaron Diaz

Our overall objective of the project is the implementation of single-cell sequencing techniques in the context of a multiomics approach that includes bulk WGS, RNAseq, and total/phospho proteomics to investigate pediatric and AYA HGG biology. Analyses will focus on biospecimens collected across m

Cellular immunity mediated by T-cells is responsible for the detection and neutralization of pathogenic threats. T-cell receptors (TCRs) are highly specialized extracellular receptors that are essential to T-cell specificity and can characterize the T-cell immune status in patients, and normal in

Our proposal develops an exciting new approach known as oncolytic virus. It is a remarkable fact that some common viruses (e.g. measles, poliovirus) preferentially infect and kill tumor cells. This fact was discovered at the beginning of the 20th century. However, it was not until recently that t