Landscape of Tumor-infiltrating T cell Repertoire of Pediatric Brain Tumors

Email Principal Investigator
All Brain Tumor Types
Asset 9.png

Gary Kohanbash

UPMC Children's Hospital of Pittsburgh
Pittsburgh, PA, USA



CBTN Participants


Brain Tumor Funders' Collaborative

St Baldrick's Foundation

About this


The cellular immune system, mediated by specialized cells called T-cells, is responsible for detecting and combating microorganisms that may cause disease such as bacteria and viruses. T-cell receptors (TCRs) are highly specialized receptors on the outside of cells. Knowledge of TCRs can characterize the T-cell immune status in patients. The ability to assess T-cell-mediated immunity in individual patients during cancer progression might enable the identification of patient-specific biomarkers that predict therapeutic efficacy and response. The extraordinary diversity of TCRs is a major bottleneck to determine the specificity of a given T cell. Understanding the immune environment, including the incidence and classification of T cell receptors of pediatric brain tumors is necessary for the development of immune-based therapies. Immune repertoire deep sequencing at the genomic DNA or cancer DNA level is limited by the availability of tumor tissue for sequencing. Access to sequencing data in the Pediatric Brain Tumor Atlas will allow researchers to complete this research and work towards new targeted therapies across pediatric brain cancer types.

Ask The


Ask the scientists

What are the goals of this project?

The goals of this project are to identify and classify T cell receptors in pediatric brain tumors, which is a necessary step in the development of immune-based therapies.

What is the impact of this project?

Through the increased knowledge of T cell receptors in pediatric brain tumors, this research will open the door to new T cell based cancer therapeutics.

Why is the CBTN request important to this project?

Quality tissue samples for DNA and RNA sequencing are rare to come by, which makes the sequencing data available through the Pediatric Brain Tumor Atlas invaluable to this work.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals