Associate Division Chief, Oncology; Neuro-Oncologist
Children's National Hospital
Eugene (Gene) Hwang, M.D., is part of the Children's National Hospital pediatric neuro-oncology team, focusing on treating children with brain tumors. Dr. Hwang has developed and led many novel early phase therapeutic clinical trials with a focus on immunotherapeutic trials, and he also leads trials focused on gene therapy and new, targeted agents. He is the site Principal Investigator of the Pediatric Brain Tumor Consortium, where he is the co-chair of the Immunotherapy Working Group.
Children’s National Hospital
Landscape of Tumor-infiltrating T cell Repertoire of Pediatric Brain Tumors
Understanding the incidence and classification of T cell receptors of pediatric brain tumors is necessary to develop new therapies. Using data from the Pediatric Brain Tumor Atlas, researchers seek to better understand the tumor cellular immune system.
All Brain Tumor Types
Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors
Scientific Reports - Nature
Harmonization of Postmortem Donations for Pediatric Brain Tumors and Molecular Characterization of Diffuse Midline Gliomas
The whole genome sequencing and RNA sequencing data related to pediatric diffuse midline gliomas that is generated by researchers on this project will be shared widely with support from CBTN.
Kambhampati M, Panditharatna E, Yadavilli S, Saoud K, Lee S, Eze A, Almira-Suarez MI, Hancock L, Bonner ER, Gittens J, Stampar M, Gaonkar K, Resnick AC, Kline C, Ho C-Y, Waanders AJ, Georgescu M-M, Rance NE, Kim Y, Johnson C, Rood BR, Kilburn LB, Hwang EI, Mueller S, Packer RJ, Bornhorst M, Nazarian J.