Searching for Differences in Molecular Profile of Pediatric Gliomas

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Nikolay Ivanov

CBTN Data Used


TL1 Grant (Award Number TL1TR002386)

About this


Childhood brain cancer is a devastating disease that is still poorly understood. Glioma is a type of brain cancer in which a specific type of cells in the brain (called glial cells), become cancerous. In our study, we will examine how the DNA in glioma cells varies between different groups of patients. We will also study how these differences in DNA affect gene expression. This will allow us to gain a greater understanding of how pediatric glioma develops, how it differs between patients, and how childhood glioma differs from adult glioma. In our research, we will utilize RNA sequencing data from pediatric gliomas from the CBTN datasets to examine glioma gene expression.

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What are the goals of this project?

In our study, we are searching for previously uncharacterized molecular subtypes of pHGG. Specifically, we will integrate the DNA methylation and transcription landscapes of pHGG to search for distinct molecular subtypes that are associated with differences in prognosis and/or specific clinical covariates. Next, we will stratify pHGG samples by clinical covariates and compare their molecular profiles with those of controls to delineate previously unknown differences that may drive tumorigenesis.

Why the CBTN request is important to this project?

The CBTN data (specifically the RNA sequencing data from pHGG samples) will be integral to the characterization of pHGG transcription landscape in our study.

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