Malignant Peripheral Nerve Sheath Tumors

(MPNSTs)

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enrolled participants

Data Projects Supported

Specimen Projects Supported

Explore Projects

Summary of

Malignant Peripheral Nerve Sheath Tumors

Malignant Peripheral Nerve Sheath Tumor, or MPNST, is a cancer of the cells that form the sheath that covers and protects peripheral nerves. Peripheral nerves are those outside of the central nervous system (brain and spinal cord). MPNST is a type of sarcoma. This cancer grows in the soft tissues of the body, such as muscle, fat, tendons, ligaments, lymph and blood vessels, nerves, and other tissue that connects and supports the body. MPSNST grows quickly and can spread to other parts of the body.

(Source: National Cancer Institute)

Available CBTN Biospecimens

participants with flash-frozen tissue available

participants with match blood

participants with match parental specimens

participants with cerebral spinal fluid

Available CBTN Pre-clinical Models

genomically characterized cell lines with data available

genomically characterized pdx with data available

How do I get access to the specimens?

To request any of the biospecimens, or pre-clinical model please fill out this form.
Request take approx. 3 months and will require review by the scientific committee and MTA.
Need help? Contact us at research@cbtn.org

Request Access to the Specimens

Explore the data in these informatics portals

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Kids First Data Resource Portal…

Kids First Portal is a search tool which allows users to explore the full availability of CBTN data and build cohorts of participants and files for further study.

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The following data are available:

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Whole Genome Sequencing

RNAseq

MRI Imaging

Tissue Slide Images

Longitudinal Clinical

How do I get access to the data?

To access the data please follow these instructions. Need help? Contact us at research@cbtn.org
You can access processed data today here by simply logging in to PedcBioPortal
You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica

Request Access to the Data

featured

Scientific Projects

Data

Ongoing

Decoding the Dark Matter of the High-Risk Paediatric Cancer Genome…

Precision oncology can be a challenge for pediatric brain tumors. Researchers will interrogate data from the Pediatric Brain Tumor Atlas in an effort to explain poor outcomes and guide treatments for patients with under-explored mutations.

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All Brain Tumor Types, (MPNSTs)

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Data

Target Identification

Ongoing

Cooperating Mutations in Brain Tumors of Patients with NF1…

Understanding the mutations that occur in both neurofibromatosis 1 patients and brain tumors could provide a deeper understanding of how both tumor types form. Using data provided by the Pediatric Brain Tumor Atlas, researchers will identify genes that are mutated in both tumor types.

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All Brain Tumor Types

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Thomas De Raedt

Children’s Hospital of Philadelphia

Philadelphia, PA, USA

Data

Ongoing

Central Nervous System Cancers in Patients with Non-Neurofibromatosis Type 1 RASopathies…

RASopathies are a group of rare genetic conditions sometimes associated with central nervous system cancers development and growth, but researchers believe their connection could be more common than previously thought. This project seeks to understand this connection through analysis of the Pediatric Brain Tumor Atlas.

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