Malignant Peripheral Nerve Sheath Tumors
Malignant Peripheral Nerve Sheath Tumor, or MPNST, is a cancer of the cells that form the sheath that covers and protects peripheral nerves. Peripheral nerves are those outside of the central nervous system (brain and spinal cord). MPNST is a type of sarcoma. This cancer grows in the soft tissues of the body, such as muscle, fat, tendons, ligaments, lymph and blood vessels, nerves, and other tissue that connects and supports the body. MPSNST grows quickly and can spread to other parts of the body.
(Source: National Cancer Institute)
Available CBTN Biospecimens
participants with flash-frozen tissue available
participants with match blood
participants with match parental specimens
participants with cerebral spinal fluid
Available CBTN Pre-clinical Models
genomically characterized cell lines with data available
genomically characterized pdx with data available
Explore the data in these informatics portals
Kids First Data Resource Portal
Kids First Portal is a search tool which allows users to explore the full availability of CBTN data and build cohorts of participants and files for further study.
The following data are available:
Whole Genome Sequencing
Tissue Slide Images
How do I get access to the data?
To access the data please follow these instructions. Need help? Contact us at firstname.lastname@example.org
You can access processed data today here by simply logging in to PedcBioPortal
You can request raw data by completing this form. The review normally takes 1 week. Once approved you can access the raw data by creating cohorts of interest on the Kids First Data Resource Portal and performing analysis on the cloud in Cavatica
Decoding the Dark Matter of the High-Risk Paediatric Cancer Genome
Precision oncology can be a challenge for pediatric brain tumors. Researchers will interrogate data from the Pediatric Brain Tumor Atlas in an effort to explain poor outcomes and guide treatments for patients with under-explored mutations.
All Brain Tumor Types, (MPNSTs)
Cooperating Mutations in Brain Tumors of Patients with NF1
Understanding the mutations that occur in both neurofibromatosis 1 patients and brain tumors could provide a deeper understanding of how both tumor types form. Using data provided by the Pediatric Brain Tumor Atlas, researchers will identify genes that are mutated in both tumor types.
All Brain Tumor Types
Thomas De Raedt
Central Nervous System Cancers in Patients with Non-Neurofibromatosis Type 1 RASopathies
RASopathies are a group of rare genetic conditions sometimes associated with central nervous system cancers development and growth, but researchers believe their connection could be more common than previously thought. This project seeks to understand this connection through analysis of the Pediatric Brain Tumor Atlas.