This project aims to identify cooperating mutations with NF1 in Neurofibromatosis type I patients with brain tumors. This project will result in a comprehensive list of genes that are co-mutated with NF1.
What are the goals of this project?
For every sequenced CBTN NF1 sample, this project aims to test every mutated gene to identify functional cooperativity with NF1.
What is the impact of this project?
This information will help model the tumors these patients develop more accurately.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Thomas De Raedt, PhD
Dr. De Raedt researches pediatric high grade glioma development and aims to understand the involvement of crucial pathways. He investigates pathway interaction, and explores ways to develop therapies through analyzing human tumors, performing cellular studies, and developing accurate mouse models
Elucidating the Role of Driver Mutations in Pediatric High Grade Glioma
High grade pediatric brain tumors (pHGG) are a devastating disease with a median survival of only 9-15 months. Importantly, pHGG represent the greatest cause of cancer related death in children under 19 years of age even though the overall incidence is low (1.78/100,000). In recent years it has b
Thomas De Raedt