Cooperating Mutations in Brain Tumors of Patients with NF1

Email Principal Investigator
Ongoing
Data
All Brain Tumor Types

About this

Project

Neurofibromatosis 1 (NF1) is a genetic disorder characterized by the development of multiple non-cancerous (benign) tumors of nerves and skin (neurofibromas) and areas of abnormal skin color (pigmentation). Understanding the mutations that occur in both NF1 and brain tumors could provide an understanding of the underlying mechanisms of the growth of both tumor types. This project will result in a comprehensive list of genes that are co-mutated with NF1. This information could then be used to research and develop improved therapeutics and outcomes for children diagnosed. This work is made possible through the provision of access to the large and comprehensive datasets in the Pediatric Brain Tumor Atlas.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Researchers are looking for mutations that occur both in brain tumors and tumors that form as a result of the genetic disorder neurofibromatosis 1.

What is the impact of this project?

The identification of co-occurring mutations could lead to advancements in the care of both tumor forms.

Why is the CBTN request important to this project?

This work is made possible through access to the large and comprehensive datasets on pediatric brain tumors in the Pediatric Brain Tumor Atlas.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals

Cavativa-Logo.png