Thomas De Raedt

PhD

Philadelphia, PA USA

About

Research Scientist ; Assistant Professor of Pediatrics

Children's Hospital of Philadelphia

Dr. De Raedt researches pediatric high grade glioma development and aims to understand the involvement of crucial pathways. He investigates pathway interaction, and explores ways to develop therapies through analyzing human tumors, performing cellular studies, and developing accurate mouse models. This allows Dr. De Raedt and his team to perform novel pre-clinical studies that can lead to clinical trials.

scientific

Projects

Specimen

Ongoing

Elucidating the Role of Driver Mutations in Pediatric High Grade Glioma…

High grade pediatric brain tumors (pHGG) are a devastating disease with a median survival of only 9-15 months. Importantly, pHGG represent the greatest cause of cancer related death in children under 19 years of age even though the overall incidence is low (1.78/100,000). In recent years it has b

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HGG…

Thomas De Raedt

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Data

Ongoing

Cooperating Mutations in Brain Tumors of Patients with NF1…

This project aims to identify cooperating mutations with NF1 in Neurofibromatosis type I patients with brain tumors. This project will result in a comprehensive list of genes that are co-mutated with NF1.

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Thomas De Raedt

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research

Interests

HGG

High-grade glioma/astrocytoma (WHO grade III/IV)…

High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effective

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Participants

Projects Supported