Aberrant splicing candidates as potential neoantigen expression in High-grade glioma

Ongoing
Data
HGG
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CBTN Data Used

About this

Project

The objective of this project is to investigate whether aberrant splicing candidates resulting from transcriptome-wide dysregulation of alternative splicing in high grade gliomas (HGGs) could be a source for novel neoantigen expression in tumors, that are distinct from missense mutations.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

We will leverage large-scale multi-omics datasets with state-of-the-art technologies to inform novel targets for CAR T-cell therapy

What is the impact of this project?

Ultimately, we hope to improve survival outcomes.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals

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