Pediatric cancer is a rare and deadly disease. This makes it challenging, or impossible, to recruit large cohorts of paediatric cancer cases, thus limiting our understanding of the biology and optimal treatment of childhood cancers. To deal with this, researchers must maximize their sample size by sharing data about pediatric brain cancers internationally. This project proposes to develop the Australian Bioinformatics Commons (AusBioCommons), in partnership with CHOP. Researchers will combine data for pediatric brain cancer cases from the ZERO Childhood Cancer Project and the Pediatric Brain Tumor Atlas, with the objective of identifying new brain cancer subtypes. This will be the largest genomic data sharing initiative ever undertaken in Australia. This project will allow data to be shared between researchers in Australia and the United States, increasing the depth of research overall.
What are the goals of this project?
The goals of this project is to increase the impact of brain cancer research by sharing data internationally through the Australian Bioinformatics Commons and completing analysis that will lead to the identification of new brain cancer subtypes.
What is the impact of this project?
The more access researchers around the world have to comprehensive data on pediatric brain cancers, the more quickly new subtypes can be identified and new treatments can be developed.
Why is the CBTN request important to this project?
Through integration of the Pediatric Brain Tumor Atlas, this project will be the largest data sharing initiative undertaken in Australia and will have international impact on the treatment of pediatric brain cancer.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
PI: Mark Cowley
Adam Resnick, PhD
Children’s Hospital of Philadelphia
Children’s Hospital of PhiladelphiaJoined on
Operations Center for the Children’s Brain Tumor Tissue Consortium, the Children’s Hospital of Philadelphia (CHOP) is currently ranked 1st nationally for their Pediatric Cancer Program by U.S. News & World Report. CHOP’s Biobank is home to the CBTTC’s pediatric brain and CNS tumor biorepository; the