Individuals who have undergone treatment for craniopharyngiomas in childhood experience lasting metabolic issues, most notably hypothalamic obesity. Hypothalamic obesity and related comorbidities including diabetes mellitus, fatty liver disease, and psychiatric disorders, impact health and quality of life of pediatric cancer survivors. Interventional studies consistently find that hypothalamic obesity is very challenging to treat. For this project, researchers will leverage the rich genetic data available through the Pediatric Brain Tumor Atlas (PBTA) to examine how background risk for obesity influences BMI trajectory in children with craniopharyngioma. Researchers propose to examine the trajectory of height, weight, and body mass index (BMI) in individuals in the PBTA with diagnoses of craniopharyngioma. The results of this project will be informative for clinicians who care for children with craniopharyngioma, will serve as a basis for proposals into future research, and is of interest to endocrinologists who focus on hypothalamic obesity.
What are the goals of this project?
Researchers will examine height, weight, and body mass index data from patients with craniopharyngioma in an effort to identify risk factors for hypothalamic obesity.
What is the impact of this project?
Understanding the risk factors that contribute to hypothalamic obesity will inform the treatment of patients with craniopharyngioma.
Why is the CBTN request important to this project?
The Pediatric Brain Tumor Atlas is a unique and comprehensive dataset on pediatric brain cancers, including craniopharyngioma. This data will serve as a foundation of this project.
The Children's Brain Tumor Network contributed to this project by providing access to the CBTN clinical data and the Pediatric Brain Tumor Atlas.
Shana McCormack, MD
Shana McCormack, MD, is an attending physician in the Division of Endocrinology and Diabetes and an assistant professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. She cares for children with pediatric endocrine disease. She has a clinical interest in patients
Children’s Hospital of Philadelphia
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Operations Center for the Children’s Brain Tumor Tissue Consortium, the Children’s Hospital of Philadelphia (CHOP) is currently ranked 1st nationally for their Pediatric Cancer Program by U.S. News & World Report. CHOP’s Biobank is home to the CBTTC’s pediatric brain and CNS tumor biorepository; the
Childhood craniopharyngiomas are rare tumors usually found near the pituitary gland (a pea-sized organ at the bottom of the brain that controls other glands) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).Craniopharyngiomas are usually part solid mass and