Comprehensive Molecular Profiling of Pediatric Diffuse Astrocytomas: Independent Validation of Proteomic AnalysisEmail Principal Investigator
Kathleen M. Schieffer
Brain tumors are the most common cause of pediatric cancer-related death in the United States, and glial tumors (astrocytomas, oligodendrogliomas, etc.) are the most common class of pediatric brain tumors. Adult low-grade diffuse astrocytomas nearly always transform into deadly, high grade glioblastomas, while pediatric tumors of the same kind are much less likely to do so. Of low-grade pediatric tumors that do not transform into high grade glioblastomas, 80% will continue to grow and progress, perhaps requiring multiple interventions. Pediatric diffuse astrocytomas are particularly hard to remove in surgery because they infiltrate normal brain tissue. Using the Pediatric Brain Tumor Atlas, researchers will conduct comparisons of tumors from children, adolescents, and young adults. Understanding the differences in how these tumors grow across age groups will help inform diagnostics and clinical care for pediatric brain cancer patients with glial tumors.
What are the goals of this project?
Researchers will assess similarities and differences in the growth of tumors in different age groups in an effort to develop targeted care for pediatric brain tumor patients.
What is the impact of this project?
There are still large gaps in what is known about pediatric tumor formation and growth. By performing comprehensive molecular profiling on this important subset of tumors, this study will provide insight regarding the molecular processes that are driving tumor formation and progression, opening the door for targeted therapies. The data and characteristics learned about this tumor type will be shared with the community.
Why is the CBTN request important to this project?
The Pediatric Brain Tumor Atlas provides researchers with a unique set of data necessary to validate their important findings.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Richard Graham, St. Jude Children's Hospital
Jessica Fleming, Ohio State University Wexner Medical Center