Diffuse intrinsic pontine glioma (DIPG) is a rare childhood brain cancer that is very often fatal. Researchers believe that ion channels, pore-forming proteins that move chemicals like calcium and potassium in and out of cells, have a role in drug resistance. Drug resistance refers to a reduction in the effectiveness of a particular treatment. Blocking ion channels may improve the efficacy of targeted therapies. Many of the ion channel drugs researchers plan to use are already approved for clinical use. This means that their approach could be rapidly moved into clinical trials, speeding up the rate at which these therapies can actually be used for patients. To complete this analysis, DIPG data will be analyzed for the expression of ion channels and clinical data will be used to ascertain basic demographic information about the samples such as sex and age. In this study, researchers will use this data from the Pediatric Brain Tumor Atlas to determine what ion channels are found in DIPG cells.
What are the goals of this project?
Researchers hope to identify DIPG associated ion channels in an effort to boost the effectiveness of targeted treatments.
What is the impact of this project?
Ion channels have a role in drug resistance and researchers believe that if ion channels can be identified and targeted, therapies for DIPG could be made more effective.
Why is the CBTN request important to this project?
The Pediatric Brain Tumor Atlas provides researchers with a unique dataset on pediatric DIPG that will be used in this research.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Terrance Johns, PhD
Dr. Johns' research interests include:understanding the biology and intracellular signalling properties of EGFR and other receptor tyrosine kinases in high-grade gliomaidentifying mechanisms of resistance to EGFR-targeted therapiescharacterizing the role of ErbB4 in high-grade gliomaevaluating CT-17
The University of Western Australia
Anya Jones, PhD, MSc
Anya's research interests include Asthma, Genomics and Systems Immunology, with a particular focus on personalised transcriptomic approaches.
Telethon Kids Institute, University of Western Australia
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with