Diffuse intrinsic pontine glioma (DIPG) is a rare childhood brain cancer that is fatal in over 99% of all cases. We believe that ion channels, pore-forming proteins that move chemicals like calcium and potassium in and out of cells, have a role in drug resistance. WE will use this data to determine what ion channels are found in DIPG cells.
What are the goals of this project?
DIPG data will be interrogated for the expression of ion channels. Clinical data will be used to ascertain basic demographic information about the samples such as sex and age.
What is the impact of this project?
Blocking ion channels may improve the efficacy of targeted therapies. Many of the ion channel drugs we plan to use are already approved for clinical use, therefore our approach could be rapidly moved into clinical trials.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Brainstem glioma- Diffuse intrinsic pontine glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[