DIPG and Other Primary Pediatric Brain Tumors
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About this
Project
Gene expression, the process by which the genetic information is used to direct production of proteins in the body, is crucial in understanding the similarities and differences across tumor types and across same-type tumor mutations. Beginning with gliomas with H3K27M mutations, researchers will investigate genes related to the immune system and their possible role in future immunotherapy, treatments that use a patient’s own immune system to attack a tumor. Access to the Pediatric Brain Tumor Atlas will give researchers important data for these investigations.
Ask The
Scientists
What are the goals of this project?
Researchers seek to better understand gene expression in many tumor types and mutations, including gliomas with H3K27M mutations.
What is the impact of this project?
A deeper understanding of a tumor’s gene expression could lead to advancements in targeted immunotherapy.
Why is the CBTN request important to this project?
The Pediatric Brain Tumor Atlas gives researchers access to the largest database of pediatric brain cancers, data that is integral to the analysis goals of this project.
Specimen Data
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Explore the data in these informatics portals
