We are evaluating expression of genes that are deferentially expressed by the effect of specific gene mutations. Especially, as the first step, we are evaluating immune-response related genes that are up-regulated or down-regulated in gliomas with H3K27M mutations. Our goal is to better understand the characteristics of those tumors and develop effective immunotherapy strategies.
What are the goals of this project?
The goal of this project is to interrogate the pediatric glioma databases for shared mutations and the effects of these mutations on downstream gene expression profiles.
Hideho Okada, MD, PhD
As a physician scientist, I have been dedicated to brain tumor immunology and development of effective immunotherapy for brain tumors for over 20 years. My team was one of very first to discover cytotoxic T lymphocyte (CTL) epitopes in glioma-associated and glioma-specific neoantigens, and found
UCSF Benioff Children's Hospital
Brainstem glioma- Diffuse intrinsic pontine glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[