Gene expression, the process by which the genetic information is used to direct production of proteins in the body, is crucial in understanding the similarities and differences across tumor types and across same-type tumor mutations. Beginning with gliomas with H3K27M mutations, researchers will investigate genes related to the immune system and their possible role in future immunotherapy, treatments that use a patient’s own immune system to attack a tumor. Access to the Pediatric Brain Tumor Atlas will give researchers important data for these investigations.
What are the goals of this project?
Researchers seek to better understand gene expression in many tumor types and mutations, including gliomas with H3K27M mutations.
What is the impact of this project?
A deeper understanding of a tumor’s gene expression could lead to advancements in targeted immunotherapy.
Why is the CBTN request important to this project?
The Pediatric Brain Tumor Atlas gives researchers access to the largest database of pediatric brain cancers, data that is integral to the analysis goals of this project.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Hideho Okada, MD, PhD
As a physician scientist, I have been dedicated to brain tumor immunology and development of effective immunotherapy for brain tumors for over 20 years. My team was one of very first to discover cytotoxic T lymphocyte (CTL) epitopes in glioma-associated and glioma-specific neoantigens, and found cri
UCSF Benioff Children's Hospital
UCSF Benioff Children's HospitalJoined on
The Pediatric Brain Tumor Center at UCSF Benioff Children’s Hospital, with campuses in San Francisco and Oakland, harnesses the power of world-class experts from all disciplines related to child brain health, including neurology, neurosurgery, neurocritical care, neurogenetics, neuro-oncology, rehab
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with