About this

Project

Gene fusions occur when two formally independent genes merge to create a new gene. These gene fusions also result in fusion proteins, proteins that may otherwise not be made by the cell. Gene fusions and their fusion proteins have been shown to play a role in the development of cancers, including pediatric brain cancers. Researchers will analyse the pediatric brain tumor RNAseq data for fusions, which may be possible therapy targets. A small cohort of the same tumors at Weill Cornell will be compared to data from the Pediatric Brain Tumor Atlas. By comparing data analysis from two sources, researchers can further verify their findings and possibly accelerate the development of therapies for pediatric brain cancers. The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Researchers will complete a comparative analysis of cancer data in an effort to find targets for new therapeutics.

What is the impact of this project?

Comparative analysis will allow researchers to verify their findings, thus accelerating the development of therapies for pediatric brain cancers.

Why is the CBTN request important to this project?

This project requires high quality data for analysis and comparison, making access to the Pediatric Brain Tumor Atlas particularly important for researchers.

Specimen Data

The Chldren's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas

Explore the data in these informatics portals

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