Genetic Polymorphisms and Neuro-Cognitive Outcomes in Pediatric Brain Tumor Survivors

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This research will evaluate associations between the presence or absence of various polymorphisms from brain tumor biospecimens and neuropsychological functioning. The study will include measures of cognitive, emotional, social and behavioral functioning through the use of direct assessment, self-, and parent- report measures. Overall, we hypothesize that pediatric brain tumor survivors will have different neurocognitive and behavioral outcomes depending on the presence or absence of genetic polymorphisms.

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What are the goals of this project?

The goals of this study are to examine the associations between various genetic polymorphisms/genotypes and neuropsychological outcomes (i.e., IQ, memory, attention, processing speed, social/emotional functioning, etc.) in pediatric brain tumor survivors

What is the impact of this project?

This study will provide valuable information on genetic polymorphisms associated with variability in neurocognitive outcomes. Information learned from the study will potentially inform clinical care of survivors of childhood brain tumors most at risk for the development of deficits in neurocognitive functioning.

Why the CBTN request is important to this project?

Each of the participants’ genomic information generated from their biospecimens will also be obtained from Children’s Brain Tumor Network (CBTN)

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas

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