Genomic Analysis of Oligodendrogilomas Across the Pediatrics, Adolescents and Adults

Email Principal Investigator
Ongoing
Specimen
Oligodendroglioma
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Adam Resnick

Children’s Hospital of Philadelphia
Philadelphia, PA, USA

CBTN Samples Used

1

CBTN Participants

2

CBTN Samples

Backer

Oligo Nation Foundation

About this

Project

Oligodendroglioma is a primary malignant brain cancer that develops from oligodendrocytes. Oligodendroglioma is one of the more common types of glioma (which also includes glioblastoma multiforme and astrocytoma). It is a rare tumor that strikes people of all ages; on average, 1,500 new cases are diagnosed per year in the United States. Rarely, families with multiple affected members have been reported, suggesting that a predisposition for oligodendroglioma can be inherited from blood relatives. Because oligodendroglioma is so rare, it has not been well-studied, due in part to a lack of available biospecimens and data for research use.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

The goal of this project is to generate whole genome sequencing with paired RNA sequencing for a cohort of Oligodendroglioma across pediatric, adolescent and adult cohort.

What is the impact of this project?

This project will create the largest open access cohort of oligodendroglioma data.

Why the CBTN request is important to this project?

There are no other specimens available in the pediatric arena

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing DNA and RNA samples for sequencing.