Germline and Somatic Determinants of Paediatric Brain Tumor Evolution

Email Principal Investigator
Tumor Evolution
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Sorana Morrissy

University of Calgary
2500 University Dr NW, Calgary, AB T2N 1N4, Canada

CBTN Specimen


CBTN Participants


CBTN Samples

CBTN Pre-clinical Models


Grants and start up funds

About this


Pediatric brain tumors such as high grade gliomas (HGG) and diffuse intrinsic pontine gliomas (DIPGS) are still poorly understood. Researchers on this project are investigating whether pediatric HGGs and DIPGS display intratumoral genetic heterogeneity (an array of distinct tumor cells within a tumor type). Understanding the heterogeneity of a tumor is important to provide proper treatment. Researchers also hope to elucidate the relationship between genetic events and how they affect the origin and progression of HGGs and DIPGs. Some of the yet to be identified genetic combinations may alter responses to drugs, and researchers seek to further study ways to utilize such findings in the advancement of cancer therapies. Current findings from this research group are interesting, but their studies are severely underpowered without additional samples, making rare tissue and germline specimens provided by The Children’s Brain Tumor Network especially important to this project.

Ask The


Ask the scientists

What are the goals of this project?

Researchers seek to better understand the genetic drivers of HGGs and DIPGs and how they evolve and progress.

What is the impact of this project?

A better understanding of tumor genetics is the first step to identifying new effective therapeutic strategies.

Why is the CBTN request important to this project?

The work being done on this project requires rare specimens unavailable nowhere but through the Children’s Brain Tumor Network.

Specimen Data

The Children's Brain Tumor Tissue Consortium contributed to this project by providing germline and tissue samples.