Germline and Somatic Determinants of Paediatric Brain Tumor Evolution

Email Principal Investigator
Ongoing
Specimen
HGG
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Sorana Morrissy

CBTN Samples Used

9

CBTN Participants

58

CBTN Samples

CBTN Pre-clinical Models Used

Backer

Grants and start up funds

About this

Project

We are investigating whether pediatric brain tumors (pHGGs, DIPGs) display intratumoral genetic heterogeneity, and the relationship between germline and somatic events as they relate to the clonal evolution of the disease.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Some of the germline-­somatic combinations may alter responses to drugs, and we thus aim to further study ways to leverage the germline events as an important aspect of pediatric tumor biology.

Why the CBTN request is important to this project?

Although our current findings are interesting, our studies are severely underpowered without additional samples. We would like to ask the CBTTC for access to pediatric brain tumor samples to help us with our studies

Specimen Data

The Children's Brain Tumor Tissue Consortium contributed to this project by providing germline and tissue samples.