We are investigating whether pediatric brain tumors (pHGGs, DIPGs) display intratumoral genetic heterogeneity, and the relationship between germline and somatic events as they relate to the clonal evolution of the disease.
What are the goals of this project?
Some of the germline-somatic combinations may alter responses to drugs, and we thus aim to further study ways to leverage the germline events as an important aspect of pediatric tumor biology.
Why the CBTN request is important to this project?
Although our current findings are interesting, our studies are severely underpowered without additional samples. We would like to ask the CBTTC for access to pediatric brain tumor samples to help us with our studies
The Children's Brain Tumor Tissue Consortium contributed to this project by providing germline and tissue samples.
Sorana Morrissy, PhD
Dr. Sorana Morrissy completed her PhD in Medical Genetics at the University of British Columbia, Vancouver, BC, under the supervision of Dr. Marco Marra. She pursued post-doctoral research in translational genomics in Dr. Michael Taylor’s lab at the Hospital of Sick Children in Toronto, ON. Thr
High-grade glioma/astrocytoma (WHO grade III/IV)
High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effective