High Dimensional Protein Characterization of Tumor Tissues and Relevance to Outcomes in Immunotherapy Clinical Trials

Email Principal Investigator
All Brain Tumor Types
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Kristina A. Cole

Children’s Hospital of Philadelphia
Philadelphia, PA, USA



CBTN Participants

About this


A tumor mass is made up of more than just the tumor cells. It also contains a variety of host cells, secreted factors and extracellular proteins that affect a tumor’s growth and response to treatment. All of these factors are collectively known as the tumour microenvironment. This collaborative project aims to examine the immune system and tumor microenvironment in pediatric brain tumor tissues, particularly in response to immunotherapy. To develop new immunotherapies, researchers must identify targets in the tumor cell that could be receptive to such treatments. Examination of the tumor microenvironment could lead to the identification of such targets. Researchers will use advanced approaches to examine tumor imagery and molecular data provided through the Pediatric Brain Tumor Atlas in the hope of advancing immunotherapy approaches for pediatric brain tumors.

Ask The


Ask the scientists

What are the goals of this project?

The goals of this project are to use and optimize the analysis of tumors, specifically as it relates to the tumor microenvironment and possible targets for immunotherapy.

What is the impact of this project?

Immunotherapy uses a patient’s own immune system to attack a tumor. Greater understanding of the molecules and cells present in the tumor microenvironment could lead to advances in this form of cancer therapy.

Why is the CBTN request important to this project?

The addition of the comprehensive dataset provided through the Pediatric Brain Tumor Atlas greatly expands the possible impact of this work across pediatric brain cancer types.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals