A tumor mass is made up of more than just the tumor cells. It also contains a variety of host cells, secreted factors and extracellular proteins that affect a tumor’s growth and response to treatment. All of these factors are collectively known as the tumour microenvironment. This collaborative project aims to examine the immune system and tumor microenvironment in pediatric brain tumor tissues, particularly in response to immunotherapy. To develop new immunotherapies, researchers must identify targets in the tumor cell that could be receptive to such treatments. Examination of the tumor microenvironment could lead to the identification of such targets. Researchers will use advanced approaches to examine tumor imagery and molecular data provided through the Pediatric Brain Tumor Atlas in the hope of advancing immunotherapy approaches for pediatric brain tumors.
What are the goals of this project?
The goals of this project are to use and optimize the analysis of tumors, specifically as it relates to the tumor microenvironment and possible targets for immunotherapy.
What is the impact of this project?
Immunotherapy uses a patient’s own immune system to attack a tumor. Greater understanding of the molecules and cells present in the tumor microenvironment could lead to advances in this form of cancer therapy.
Why is the CBTN request important to this project?
The addition of the comprehensive dataset provided through the Pediatric Brain Tumor Atlas greatly expands the possible impact of this work across pediatric brain cancer types.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Crystal L Mackall
Robert Michael Angelo
Pier Federico Gherardini,
Kristina A. Cole, MD, PhD
Kristina Cole, MD, PhD is a pediatric oncologist who has dedicated her career to translational and clinical research, combining her expertise in molecular pathology, cancer genomics, and developmental therapeutics to identify novel treatments for children with cancer. The long-term goal of Dr. Cole’
Children’s Hospital of Philadelphia
Children’s Hospital of PhiladelphiaJoined on
Operations Center for the Children’s Brain Tumor Tissue Consortium, the Children’s Hospital of Philadelphia (CHOP) is currently ranked 1st nationally for their Pediatric Cancer Program by U.S. News & World Report. CHOP’s Biobank is home to the CBTTC’s pediatric brain and CNS tumor biorepository; the