Kristina A. Cole

MD, PhD
Scientific Committee

Philadelphia, PA USA

Children’s Hospital of Philadelphia

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About

Pediatric Neuro-oncologist

The Children's Hospital of Philadelphia

Kristina Cole, MD, PhD is a pediatric oncologist who has dedicated her career to translational and clinical research, combining her expertise in molecular pathology, cancer genomics, and developmental therapeutics to identify novel treatments for children with cancer. The long-term goal of Dr. Cole’s research team and collaborators is to identify effective therapies and improve the cure rate of children with malignant brain tumors.

Specific Areas of Interest: Clinical translation of molecular targets, single-cell analysis of pediatric solid tumors, and studies of pediatric malignant glioma with ATRX deficiency

Expertise

Neuro-oncology

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Children’s Hospital of Philadelphia

Philadelphia, PA, USA

scientific

Projects

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Data

Ongoing

Defining the Mutational Landscape of Pediatric Brain Tumors

Information regarding the mutations of genes in pediatric brain tumors is integral in developing new diagnostics and treatments. Researchers will use the Pediatric Brain Tumor Atlas to analyze comprehensive genetic information across pediatric brain tumor types, which will be used by researchers in the development of new treatments.

All Brain Tumor Types

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Sharon J. Diskin

Children’s Hospital of Philadelphia
Philadelphia, PA, USA
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Data

Specimen

Ongoing

Center for Pediatric Tumor Cell Atlas

In order to make therapeutic advancements, comprehensive research must be conducted to molecularly understand tumors. The Center for Pediatric Tumor Cell Atlas project, part of the Human Tumor Atlas Network of the NIH Cancer Moonshot initiative will utilize rare samples provided by the Children’s Brain Tumor Network to better understand pediatric high grade gliomas and neuroblastomas.

HGG

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Kristina A. Cole

Children’s Hospital of Philadelphia
Philadelphia, PA, USA
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Specimen

Ongoing

Targeting Replicative Stress in Pediatric Brain Tumors with ALT

There are many molecules associated with cell division that could serve as targets for cancer therapy. Researchers will analyze specimens provided by the Children’s Brain Tumor Network to determine whether drugs that inhibit such molecules could increase radiation sensitivity in pediatric brain cancer patients and improve outcomes.

HGG

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Kristina A. Cole

Children’s Hospital of Philadelphia
Philadelphia, PA, USA
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Data

Ongoing

Telomere Maintenance Across Multiple Brain Tumors

A greater understanding of the abundance of telomeres and their relationship to the growth of high grade gliomas (HGG) could lead to new therapies. Using the Pediatric Brain Tumor Atlas, this study seeks to build this knowledge for use by researchers around the world.

HGG

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Kristina A. Cole

Children’s Hospital of Philadelphia
Philadelphia, PA, USA
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New

Data

Ongoing

High Dimensional Protein Characterization of Tumor Tissues and Relevance to Outcomes in Immunotherapy Clinical Trials

The tumor microenvironment includes the variety of molecules and cells found within a tumor mass. Researchers are examining data provided through the Pediatric Brain Tumor Atlas in an effort to identify therapeutic targets for many forms of pediatric brain cancer.

All Brain Tumor Types

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Kristina A. Cole

Children’s Hospital of Philadelphia
Philadelphia, PA, USA