Kristina A. Cole
About
Pediatric Neuro-oncologist
The Children's Hospital of Philadelphia
Kristina Cole, MD, PhD is a pediatric oncologist who has dedicated her career to translational and clinical research, combining her expertise in molecular pathology, cancer genomics, and developmental therapeutics to identify novel treatments for children with cancer. The long-term goal of Dr. Cole’s research team and collaborators is to identify effective therapies and improve the cure rate of children with malignant brain tumors.
Specific Areas of Interest: Clinical translation of molecular targets, single-cell analysis of pediatric solid tumors, and studies of pediatric malignant glioma with ATRX deficiency
Expertise
Neuro-oncology
Children’s Hospital of Philadelphia
scientific
Projects
Data
Ongoing
Defining the Mutational Landscape of Pediatric Brain Tumors
Information regarding the mutations of genes in pediatric brain tumors is integral in developing new diagnostics and treatments. Researchers will use the Pediatric Brain Tumor Atlas to analyze comprehensive genetic information across pediatric brain tumor types, which will be used by researchers in the development of new treatments.
All Brain Tumor Types
Sharon J. Diskin
Data
Specimen
Ongoing
Center for Pediatric Tumor Cell Atlas
In order to make therapeutic advancements, comprehensive research must be conducted to molecularly understand tumors. The Center for Pediatric Tumor Cell Atlas project, part of the Human Tumor Atlas Network of the NIH Cancer Moonshot initiative will utilize rare samples provided by the Children’s Brain Tumor Network to better understand pediatric high grade gliomas and neuroblastomas.
HGG
Kristina A. Cole
Specimen
Ongoing
Targeting Replicative Stress in Pediatric Brain Tumors with ALT
There are many molecules associated with cell division that could serve as targets for cancer therapy. Researchers will analyze specimens provided by the Children’s Brain Tumor Network to determine whether drugs that inhibit such molecules could increase radiation sensitivity in pediatric brain cancer patients and improve outcomes.
HGG
Kristina A. Cole
Data
Ongoing
Telomere Maintenance Across Multiple Brain Tumors
A greater understanding of the abundance of telomeres and their relationship to the growth of high grade gliomas (HGG) could lead to new therapies. Using the Pediatric Brain Tumor Atlas, this study seeks to build this knowledge for use by researchers around the world.
HGG
Kristina A. Cole
Data
Ongoing
High Dimensional Protein Characterization of Tumor Tissues and Relevance to Outcomes in Immunotherapy Clinical Trials
The tumor microenvironment includes the variety of molecules and cells found within a tumor mass. Researchers are examining data provided through the Pediatric Brain Tumor Atlas in an effort to identify therapeutic targets for many forms of pediatric brain cancer.
All Brain Tumor Types
Kristina A. Cole
