Defining the Mutational Landscape of Pediatric Brain Tumors

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In this study, Dr. Diskin and her team are performing a primary analysis of recently-generated whole genome sequencing (WGS) and matched RNA-sequencing. This study will take advantage of the various cancer types sequenced to identify pleotropic and histotypes-specific alterations, somatic drivers and cancer type/subtype markers. Pathway analyses will be done using genes predicted to be effected by somatic mutations. Germline and somatic structural variations will be classified by histotypes and correlated with disease subtypes. Known and novel transcripts will be evaluated for differential expression, expressed mutations, and fusion events within and across histotypes.

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What are the goals of this project?

The goal of this project is to define the mutational landscape across the diverse cancers sequenced and to identify pleotropic and/or histotypes-specific alterations driving the development and progression of central nervous system cancers in pediatric populations

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals