Molecular characterization of choroid plexus tumors

Choroid plexus tumors
Choroid Plexus Tumors
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CBTN Data Used

About this


My institution serves as reference neuropathology center for the international choroid plexus tumor registry (CPT-SIOP, International Society of Pediatric Oncology) and we thus frequently encounter CPT tissue samples. Previously, we have shown that methylation profiling of CPT reveals three clinically distinct subgroups (Neuro Oncol. 2016 Jun;18(6):790-6.), but, however, despite frequent copy-number alterations and some CPTs harboring TP53 mutations, no recurrent driver mutations are on record.

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What are the goals of this project?

To this end, the aim of our project is to evaluate the occurrence of fusion transcripts in CPT. After performing fusion calling per sample, we will analyze the set intersections of all tools.

What is the impact of this project?

The results are expected to shed light on the pathogenesis of choroid plexus tumors and testing the hypothesis of recurrent fusion transcripts.

Why the CBTN request is important to this project?

High-quality fresh-frozen material suitable for deep RNA and DNA sequencing is sparse. Therefore, we apply for the choroid plexus papilloma and choroid plexus carcinoma datasets from CBTN.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

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