Our focus is on ependymoma, a pediatric brain tumor, for which still today subgroups exist where no clear drivers or drug targets have been identified. However, we would like to consider our results also in the context of other brain tumors.
What are the goals of this project?
The goal of this project is to identify transcript isoforms that are only present in specific subtypes of ependymoma.
What is the impact of this project?
At the end of the project, we would like to have more insights in what is driving ependymomas or subtypes of these that could lead to better treatment options and a better outcome for patients.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumo