Targeting Master Regulator Dependencies in Diffuse Intrinsic Pontine Glioma (DIPG)

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CBTN Data Used


Hyundai Hope on Wheels Foundation Grant

Swim Across America Young Investigator Award

Gary Fegel Foundation Donation

About this


DIPG remains a fatal disease and new treatment approaches are necessary. A novel Cancer Systems Biology approach identifies master regulator (MR) proteins that are necessary for tumor growth and predicts and prioritizes drugs that reverse their effects. This study will apply such an approach to evaluate new treatment strategies in DIPG.

Ask The


Ask the scientists

What are the goals of this project?

We will analyze the PBTA-CBTN and other DIPG gene expression data using innovative computational algorithms to describe the landscape of MR proteins in DIPG tumors and prioritize drugs by their ability to shut down the most aberrant MR proteins both in individual patient samples and across the disease as a whole. We will evaluate the efficacy of treatments predicted by the MR approach in patient-derived DIPG cell lines and animal models.

What is the impact of this project?

This will advance drug development and suggest novel therapy approaches in DIPG to improve outcomes in this difficult-to-treat disease.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals