Children's Hospital of Philadelphia
Ammar’s research focuses on combining his interdisciplinary expertise in Bioinformatics, RNA biology and cancer. His broad research interests are focused on understanding regulatory and transcriptional mechanisms that contribute to oncogenesis, tumor evolution and progression in pediatric cancers. He hopes in elucidating these fundamental processes, that will then inform therapeutic regimens and/or lead to novel therapeutics.
Molecular Mechanisms and Functional Impact of Aberrant Splicing in Diffuse Midline Gliomas
A comprehensive approach is needed to advance the understanding and clinical care options for patients with diffuse midline gliomas (DMGs). Using DMG samples provided by the Children’s Brain Tumor Network, researchers seek to identify avenues for new therapies.
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with