Dr. Carter, research scientist at the pediatric neuro-oncology laboratory at Hackensack Meridian Health Center for Discovery and Innovation (CDI), possesses a rare translational background that combines expertise in analytical chemistry and biomedical training. Her research interest centers on analytical chemistry, with a particular focus on mass spectrometry imaging (MSI) and how this is utilized at the chemistry-biology interface to probe disease mechanisms and pharmaceutical PK/PD studies. She has made seminal contributions in the fields of mass spectrometry and normal-tissue radiation injury. Dr. Carter published the first manuscript applying MSI to samples prepared using standard clinical pathology protocols, which was instrumental in driving MSI to the level of clinical application for lipidomic investigations. Dr. Carter developed methods that allowed high-resolution mass spectrometry imaging of inflated lung biopsy samples for biomarker and pharmaceutical studies. These investigations also led to the identification of a panel of key biological markers of radiation injury that spanned different pathologies and offered insights into the mechanism of action.
Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center
Elucidating the ETMR Microenvironment using Next Generation Imaging and Multi-omics Technologies
The tumor microenvironment, the cells and molecules surrounding a tumor, can provide great insight into possible therapies. Using data and samples from CBTN, researchers will assess the tumor microenvironment of embryonal tumors with multilayered rosettes. (ETMR)
Embryonal Tumor with Multilayered Rosettes
Nonmedulloblastoma embryonal tumors are fast-growing tumors that usually form in brain cells in the cerebrum, and most commonly occur in young children. The cerebrum is at the top of the head and is the largest part of the brain. The cerebrum controls thinking, learning, problem-solving, emotions, s