Assistant Professor, Pediatrics
Wake Forest Baptist Health
David Kram is a pediatric neuro-oncologist and Medical Director of the Pediatric Brain Tumor Program at Wake Forest School of Medicine/Brenner Children’s Hospital. David’s research focuses on infant and pediatric glioma behavior, invasiveness, and response to therapy. He is committed to finding better treatments with fewer side effects for children with brain tumors.
Before joining the faculty at Wake Forest School of Medicine/Brenner Children’s Hospital, he earned his MD at Tel Aviv University in Israel, and his MCR at Oregon Health & Science University, where he also completed his fellowship in pediatric hematology/oncology
Enabling Replicative Immortality
Oncogene-Induced Senescence in RTK-fused Infant High Grade Gliomas
Senescence refers to a cell that is in a stage where they do not divide, and researchers believe senescence could have a roll in the different behaviors of glioma in pediatric patients vs. adult patients. Using rare specimens from infants and children provided by the Children’s Brain Tumor Network, researchers will analyze senescence in glioma tissues in comparison to adult cancers.