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David Kram

Wake Forest Baptist Health
Winston-Salem, NC, USA

CBTN Specimen

14

CBTN Participants

12

CBTN Samples

CBTN Pre-clinical Models

Backer

WFBMC Start-Up Funding

About this

Project

The goals of the project are to compare expression of senescence biomarkers in glioma tissue samples. Senescence refers refers to a cell that is in a stage where they do not divide. Researchers suggest that senescence contributes to the different behaviors and outcomes of infant and pediatric/adult glioma. The mechanism responsible for this difference in senescence induction between infant, pediatric, and adult glioma cells will be further investigated. Using frozen tissue, researchers will compare expression of senescence biomarkers in glioma tissue samples and correlate prevalence of senescent markers with glioma aggressiveness. Using the cell lines, researchers will analyze the effects that genetic manipulations have on senescence and tumor growth in primary human gliocytes and cell lines derived from HGG tissues. The Children’s Brain Tumor Network will make this work possible through the provision of 12 flash frozen tissue samples and 2 suspended cell pellets.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

This project aims to better understand the connection between senescences and glioma aggressiveness across infants, children and adults.

What is the impact of this project?

Understanding these connections could lead to advancements in diagnostics, prognostics, and therapies for glioma patients.

Why is the CBTN request important to this project?

The rare, high quality specimens provided by the Children’s Brain Tumor Network are necessary for researchers to carry out this work.

Specimen Data

CBTN will be contributing to this project by providing 12 flash frozen tissue samples and 2 suspended cell pellets.