Wake Forest School of Medicine
Cellular defense and metabolism, Aberrant signaling pathways in tumor cells, Cell growth and survival, Molecular cancer epidemiology, Gene-environment interactions, Cancer control
Wake Forest Baptist Health
Oncogene-Induced Senescence in RTK-fused Infant High Grade Gliomas
Senescence refers to a cell that is in a stage where they do not divide, and researchers believe senescence could have a roll in the different behaviors of glioma in pediatric patients vs. adult patients. Using rare specimens from infants and children provided by the Children’s Brain Tumor Network, researchers will analyze senescence in glioma tissues in comparison to adult cancers.
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test