Wake Forest School of Medicine
Cellular defense and metabolism, Aberrant signaling pathways in tumor cells, Cell growth and survival, Molecular cancer epidemiology, Gene-environment interactions, Cancer control
Oncogene-Induced Senescence in RTK-fused Infant High Grade Gliomas
While the recent discoveries suggest that iHGG harboring RTK-fusions may be a distinct population of potentially favorable tumors with more benign natural histories and sensitivity to tyrosine-kinase inhibitors, this biology neither explains this behavior nor provides sufficient evidence to avoid the classic, and possibly excessive, treatment approach for HGG, which includes surgery, radiation, and alkylator-based chemotherapy for this exceptionally vulnerable population. As such, deeper understanding into the mechanisms of iHGG initiation, growth, and maturation or progression is desperately needed.
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test