Our research group is exploring how MYC proteins are stabilized in malignant brain tumors with a focus on identifying cells of tumor origin. We further study critical pathways involved in tumor recurrence and new treatments for MYC/MYCN-driven brain tumors. We have generated clinically relevant models for MYC/MYCN-driven brain tumors and we also study a large number of primary cell lines obtained from childhood brain tumor patients.
Clinical Research, Neuro-oncology, Pathology
Comparison of CBTN Patient Data with Molecularly-Defined Stem Cell Models of Pediatric Brain Tumors
Preclinical models are a common way for researchers to study tumor types as well as test diagnostics and therapies. Researchers seek to validate their preclinical models for malignant pediatric tumors through comparison to patient-derived tumor data housed in the Pediatric Brain Tumor Atlas.
Medulloblastoma, HGG, DIPG, Choroid Plexus Tumors