Comparison of CBTN patient data with molecularly defined stem cell models of pediatric brain tumors

Ongoing
Data
Medulloblastoma
HGG
DIPG
Choroid Plexus Tumors
Asset 15.png

CBTN Data Used

Backer

ERC Starting Grant

Swedish Research Council

Swedish Cancer Society

About this

Project

We are currently generating various models of malignant childhood brain tumors in mice. We mainly focus on medulloblastoma but are also studying malignant glioma, DIPGs and choroid plexus carcinomas. Our focus is on the signaling pathways of MYC and MYCN cancer genes that are commonly dysregulated in childhood brain tumors. We would like to compare patient-derived gene expression profiles (from CBTN) to data generated from our animal models.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

We have analyzed tumors of our mouse models using RNA sequencing and methylation profiling. We would like to compare these to patient-derived data to see if they resemble a certain entity of human pediatric brain tumors. This information is helpful for us to clarify that our models are accurate and clinically relevant.

What is the impact of this project?

We hope to generate models for various types of childhood brain tumors in order to understand how they develop and if we can find novel targets for potential novel treatments.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals

Cavativa-Logo.png
kidsfirstdrc_logo.png

related

Histologies