Comparison of CBTN Patient Data with Molecularly-Defined Stem Cell Models of Pediatric Brain Tumors

Choroid Plexus Tumors
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ERC Starting Grant

Swedish Research Council

Swedish Cancer Society

About this


Preclinical models are a common way for researchers to study tumor types as well as test diagnostics and therapies. Researchers are currently developing various models of malignant pediatric tumors such as medulloblastoma, malignant glioma, diffuse intrinsic pontine gliomas (DIPG) and choroid plexus carcinomas. The focus of this research is on the signaling pathways of MYC and MYCN cancer genes. These pathways are commonly dysregulated in childhood brain tumors and a deeper understanding of this dysregulation could lead to more accurate diagnoses and new therapeutics. Researchers will compare patient-derived gene expression profiles housed in the Pediatric Brain Tumor Atlas to data generated from models. This will allow researchers to validate that their newly developed models are accurate and relevant to medical professionals.

Ask The


Ask the scientists

What are the goals of this project?

Researchers seek to validate the accuracy of newly developed preclinical models for malignant brain tumors.

What is the impact of this project?

This research will allow researchers to make sure that newly developed models will be accurate and relevant. Robust preclinical models are important for understanding drug interactions in pediatric brain cancer patients and to support the discovery of new therapeutics.

Why is the CBTN request important to this project?

To validate their newly developed models, researchers will compare preclinical model derived data to comprehensive pediatric cancer data available through the Pediatric Brain Tumor Atlas.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals