We are currently generating various models of malignant childhood brain tumors in mice. We mainly focus on medulloblastoma but are also studying malignant glioma, DIPGs and choroid plexus carcinomas. Our focus is on the signaling pathways of MYC and MYCN cancer genes that are commonly dysregulated in childhood brain tumors. We would like to compare patient-derived gene expression profiles (from CBTN) to data generated from our animal models.
What are the goals of this project?
We have analyzed tumors of our mouse models using RNA sequencing and methylation profiling. We would like to compare these to patient-derived data to see if they resemble a certain entity of human pediatric brain tumors. This information is helpful for us to clarify that our models are accurate and clinically relevant.
What is the impact of this project?
We hope to generate models for various types of childhood brain tumors in order to understand how they develop and if we can find novel targets for potential novel treatments.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
PI: Fredrik Swartling
Brian Rood, MD
Brian R. Rood, MD, is an Associate Professor of Pediatrics in the Center for Cancer and Blood Disorders at Children’s National Hospital whose primary clinical focus is pediatric neuro-oncology. Dr. Rood joined the faculty of Children’s National in 2002 after completing a fellowship in Pediatric H
Children’s National Hospital
Medulloblastomas comprise the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinica
High-grade glioma/astrocytoma (WHO grade III/IV)
High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effective
Brainstem glioma- Diffuse intrinsic pontine glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[
Choroid Plexus Tumors
Choroid Plexus Carcinoma (Grade III)
Choroid plexus tumors occur in both children and adults, but are more common in children in the first year of life. Choroid plexus tumors occur slightly more often in females than males.The cause of most choroid plexus tumors is not known. Genetic changes have been linked to the formation