Medical Director, Brain Tumor Institute
Children’s National Hospital
Brian R. Rood, MD, is an Associate Professor of Pediatrics in the Center for Cancer and Blood Disorders at Children’s National Hospital whose primary clinical focus is pediatric neuro-oncology. Dr. Rood joined the faculty of Children’s National in 2002 after completing a fellowship in Pediatric Hematology/Oncology as well as a research fellowship in the molecular biology of brain tumors, both at Children’s National and Children’s National Research Institute.
Dr. Rood is the Medical Director of Brain Tumor Institute at Children’s National and cares for brain tumor patients on the inpatient oncology ward and in the outpatient clinic. He is co-principal investigator with Eugene Hwang, M.D., of the Pediatric Brain Tumor Consortium clinical trial program at Children’s National and runs an active molecular biology and proteogenomics lab in the Center for Cancer and Immunology Research of the Children’s National Research Institute. His lab is focused on investigating the proteome of medulloblastoma, the most common malignant brain tumor of childhood, in order to detect unique proteins resulting from genomic aberrations in the tumor cells. These proteins can be used as drug targets, neoantigens for T cell immunotherapies and tumor specific biomarkers that reflect the presence of residual or recurrent cancer cells. Dr. Rood also is working to identify microsatellite markers in a person’s DNA that predict the risk of developing different kinds of brain tumors.
Dr. Rood has two children. His favorite past times include designing and building furniture, sailing, reading, and playing the mandolin.
Proteomic Analysis of CBTN Cell Lines (Procan)
Scientists at Children’s Medical Research Institute are analysing tens of thousands of examples of all types of cancer from all over the world to develop a library of information to advance scientific discovery and enhance clinical treatment worldwide.This database will mean doctors can ef
HGG, Atypical teratoid/rhabdoid tumor (AT/RT)
Children's Brain Tumor Network Pediatric Brain Tumor Proteomics Pilot
Pediatric brain tumors are the leading cause of disease related death in children. Major factors contributing to treatment failures for children with brain tumors include: i) the lack of comprehensive molecular description of the disease and an associated dearth of integration of the tumors’ biol
Craniopharyngioma, Medulloblastoma, HGG, Atypical teratoid/rhabdoid tumor (AT/RT), LGG, Ependymoma, Ganglioglioma, DNET, Schwannoma
Integrative functional genomics of recurrent childhood medulloblastoma
Irrespective of entity, patients who relapse from cancer have an extremely dismal outlook, with nearly all patients succumbing to their recurrent disease. This is particularly true for patients with medulloblastoma (MB), the most common malignant brain tumor in children, where tumor relapse is am
Comparison of CBTN patient data with molecularly defined stem cell models of pediatric brain tumors
We are currently generating various models of malignant childhood brain tumors in mice. We mainly focus on medulloblastoma but are also studying malignant glioma, DIPGs and choroid plexus carcinomas. Our focus is on the signaling pathways of MYC and MYCN cancer genes that are commonly dysregulate
Medulloblastoma, HGG, DIPG, Choroid Plexus Tumors
Proteogenomic Identification of Structural Variations
Cancers commonly arise as the result of changes affecting the DNA sequence of cells including single nucleotide variations, small insertions and deletions, and structural variations including deletions, duplications, inversions, and translocations. In addition to these, cancer specific splicing a
Germline and Somatic Microsatellite Genotypes in Pediatric Brain Tumors
Microsatellites consist of a 1-6 base pair unit repeated in tandem to form an array. Over 600,000 unique microsatellites exist in the human genome, and are often embedded in gene introns, exons, and regulatory regions. Interestingly, the length of microsatellite loci frequently change due to stra
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinic
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
We report a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 histological types of childhood brain cancer: low-grade glioma (n = 93), ependymoma (32), high-grade glioma (25), medullobla
Francesca Petralia, Nicole Tignor, Boris Reva, Mateusz Koptyra, Shrabanti Chowdhury, Dmitry Rykunov, Azra Krek, Weiping Ma, Yuankun Zhu, Jiayi Ji, Anna Calinawan, Jeffrey R. Whiteaker, Antonio Colaprico, Vasileios Stathias, Tatiana Omelchenko, Xiaoyu Song, Pichai Raman, Yiran Guo, Miguel A. Brown, Richard G. Ivey, John Szpyt, Sanjukta Guha Thakurta, Marina A. Gritsenko, Karl K. Weitz, Gonzalo Lopez, Selim Kalayci, Zeynep H. Gümüş, Seungyeul Yoo, Felipe da Veiga Leprevost, Hui-Yin Chang, Karsten Krug, Lizabeth Katsnelson, Ying Wang, Jacob J. Kennedy, Uliana J. Voytovich, Lei Zhao, Krutika S. Gaonkar, Brian M. Ennis, Bo Zhang, Valerie Baubet, Lamiya Tauhid, Jena V. Lilly, Jennifer L. Mason, Bailey Farrow, Nathan Young, Sarah Leary, Jamie Moon, Vladislav A. Petyuk, Javad Nazarian, Nithin D. Adappa, James N. Palmer, Robert M. Lober, Samuel Rivero-Hinojosa, Liang-Bo Wang, Joshua M. Wang, Matilda Broberg, Rosalie K. Chu, Ronald J. Moore, Matthew E. Monroe, Rui Zhao, Richard D. Smith, Jun Zhu, Ana I. Robles, Mehdi Mesri, Emily Boja, Tara Hiltke, Henry Rodriguez, Bing Zhang, Eric E. Schadt, D.R. Mani, Li Ding, Antonio Lavarone, Maciej Wiznerowicz, Stephan Schürer, Xi S. Chen, Allison P. Heath, Jo Lynne Rokita, Alexey I. Nesvizhskii, David Fenyö, Karin D. Rodland, Tao Liu, Steven P. Gygi, Amanda G. Paulovich, Adam C. Resnick, Phillip B. Storm, Brian R. Rood, Pei Wang, Children’s Brain Tumor Network, Clinical Proteomic Tumor Analysis Consortium