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Roger Reddel

CBTN Data Used

Backer

Grant from New South Wales Ministry of Health

Cancer Moonshot Proteogenomics Program Grant

About this

Project

Scientists at Children’s Medical Research Institute are analysing tens of thousands of examples of all types of cancer from all over the world to develop a library of information to advance scientific discovery and enhance clinical treatment worldwide.

This database will mean doctors can effectively narrow down the best type of currently available treatment to target a cancer patient’s individual diagnosis, without having to waste time trialing medications that won’t effectively treat the disease.Working with leading cancer researchers throughout Australia and around the world, the Centre is analysing samples of all types of cancer, starting with cancers of childhood.

Advanced data science and software engineering will be used to compare the protein data with the de-identified information that is already available for each cancer, including clinical records such as pathology test results, genetic analyses, genome sequencing, and any previous responses to cancer treatment. This proteogenomics approach to understanding cancer is crucial to speeding up the search for cures

Ask The

Scientists

Ask the scientists

What are the goals of this project?

The goals of this project are to use a combination of proteomics and drug sensitivity data to learn how to predict outcome of paediatric brain cancers to treatment and compare the proteomes of paediatric brain cancer cell lines to the proteomes of the tumours from which they were derived; this will assist the deconvolution of proteomic data obtained from tumours which are a complex mixture of cancer cells and other cell types. This project also aims to correlate the proteomic and genomic data and contribute to the database of 'omic data being made available for paediatric cancer through the Kids First Data Resource Center.

What is the impact of this project?

In combination with the proteomics data generated through other CBTTC projects (such as CBTN Pediatric Brain Tumor Proteomics Pilot) and CBTN collaboration with NCATS, this new data set will provide a valuable resource to the scientific community.

Why the CBTN request is important to this project?

CBTTC is a source of very well‐annotated pediatric cancer samples that will be an invaluable addition to the ProCan pan‐cancer survey. Conversely, ProCan can add proteomic data to the Kids First Data Resource.

Specimen Data

The Children's Brain Tumor Network will contribute to this project by providing cell lines.

Explore the data in these informatics portals

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