Microsatellites are repeating units of base pairs found in DNA and over 600,000 microsatellites exist in the human genome. The location of these microsatellites can change and those changes could eventually lead to changes in gene expression by altering the way that RNA and proteins can attach to a gene. Past Genome-wide Associated Studies (GWAS) have ignored repetitive DNA such as microsatellites, however recent studies have shown a linkage between the length of microsatellites can contribute to the development of several cancers. Researchers will interrogate genomic information from the Pediatric Brain Tumor Atlas to identify the loci of pediatric brain cancer associated microsatellites. Understanding this connection could lead to new diagnostics and treatments for pediatric brain tumors.
What are the goals of this project?
Researchers will analyze pediatric brain cancer data to identify the location of microsatellites and characterize them across tumor types, which could play an important role in cancer development.
What is the impact of this project?
Understanding the connection of microsatellite loci and cancer development could lead to the development of more accurate diagnostics and new treatments.
Why is the CBTN request important to this project?
The Pediatric Brain Tumor Atlas provides researchers with the comprehensive dataset on pediatric brain cancers necessary to complete this work.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Other collaborators: Nick Kinney, Virginia College of Osteopathic Medicine
Children’s National HospitalJoined on
Each year, the Brain Tumor Institute at Children’s National evaluates more than 100 new patients with brain tumors, and is recognized as a world leader in childhood brain tumor care and research. Children’s National has pioneered novel pediatric brain tumor therapies, including new molecularly-targe