Children's National Hospital
Samuel Rivero-Hinojosa, Ph.D., is a Staff Scientist at the Children’s National Research Institute focused on pediatric brain tumors. He is interested on integrative bioinformatics for Genomic and Proteomics to discover the functional biology and new treatment options for childhood brain tumors. He has special a interest in developing proteogenomic approaches to discover neoantigens for immunotherapy targeting and biomarker development.
Children’s National Hospital
Proteogenomic Identification of Structural Variations
Changes to DNA that can give rise to cancers often create fusion proteins, proteins that may be useful as therapeutic targets. Using data from the Pediatric Brain Tumor Atlas, researchers will analyze for the presence of such proteins in an effort to advance treatment options for pediatric brain cancers.
Germline and Somatic Microsatellite Genotypes in Pediatric Brain Tumors
Studies have shown a link between microsatellites, repeating units of DNA, and the development of several cancer types. Researchers will access the Pediatric Brain Tumor Atlas in an effort to identify the location of microsatellites and deepen the understanding of their connection to cancer development across brain tumor types.
All Brain Tumor Types
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature