Children's National Hospital
Samuel Rivero-Hinojosa, Ph.D., is a Staff Scientist at the Children’s National Research Institute focused on pediatric brain tumors. He is interested on integrative bioinformatics for Genomic and Proteomics to discover the functional biology and new treatment options for childhood brain tumors. He has special a interest in developing proteogenomic approaches to discover neoantigens for immunotherapy targeting and biomarker development.
Proteogenomic Identification of Structural Variations
Cancers commonly arise as the result of changes affecting the DNA sequence of cells including single nucleotide variations, small insertions and deletions, and structural variations including deletions, duplications, inversions, and translocations. In addition to these, cancer specific splicing a
Germline and Somatic Microsatellite Genotypes in Pediatric Brain Tumors
Microsatellites consist of a 1-6 base pair unit repeated in tandem to form an array. Over 600,000 unique microsatellites exist in the human genome, and are often embedded in gene introns, exons, and regulatory regions. Interestingly, the length of microsatellite loci frequently change due to stra
Medulloblastomas comprise the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinica