Medical University of Gdansk
High throughput transcriptomic and epigenomic data
Disclosing Chromatin Accessibility in Brain Tumor Cells after Treatment by Cracking a 'Nucleosomal Code'
Pediatric high grade gliomas are particularly challenging to treat. This project will utilize rare samples provided by the Children’s Brain Tumor Network to explore pHGG response to cancer treatments.
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test