Sumanth Nagabushan

Germinomas are a rare pediatric brain cancer with high rates of relapse, the process by which a cancer returns after successful treatment. Researchers across the United states, Australia, and Brazil will be requested to contribute data as researchers aim to curate a database of information related to relapsed central nervous system germinomas. Reports of relapsed germinomas are rare and exist in two main contexts, as part of a large trial or within case reports. There is, to the researchers knowledge, no large, multi-institutional database that focus on relapsed germinomas. Having this specific data including patients from different institutions and who received varying types of treatments available for analysis could provide new insight into the biology of germinomas and new avenues for treatment. Pulling this information together could also help researchers and clinical professionals evaluate patterns in the germinoma patient population such as location, timing, and treatment related to cases of relapse. The CBTN database encompasses germinoma cases from multiple institutions and trials therefore supports the efficiency and impact of this project.