Medulloblastoma is the most common childhood cancer in the brain and despite recent advances in therapeutic outcomes, survival rates are reaching a plateau. To improve survival outcomes, a greater understanding of the biology and progression of medulloblastoma is greatly needed. Recent research has found that newly identified RNA molecules, circular RNAs, play a role in an increasing number of cancers such as hepatocellular carcinoma, prostate and breast cancer. Researchers hypothesize that circular RNAs will also have a functional role in medulloblastoma and may even be used as biomarkers and therapeutic targets. The goals of this project are to identify the circular RNA present in medulloblastoma tumors of the sonic hedgehog (SHH) subgroup and compare it with that of normal cerebellum and to generate RNAseq data. This project will generate the largest open-access dataset of circular RNAs in SHH medulloblastoma. The Children's Brain Tumor Network contributed to this project by providing tumor RNA samples from patients with SHH medulloblastomas.
What are the goals of this project?
The goal of this project is to identify the circular RNA present in medulloblastoma tumors of the sonic hedgehog (SHH) subgroup and to generate RNA sequencing data that can be used to further research.
What is the impact of this project?
This project will generate the largest open access data set of its kind, contributing to an acceleration in the discovery of new therapeutic targets for medulloblastoma.
Why is the CBTN request important to this project?
This project requires rare samples from a specific subset of tumors, SHH medulloblastomas, only available through a resource such at the Children’s Brain Tumor Network.
The Children's Brain Tumor Network contributed to this project by providing tumor RNA samples.
Peter George Zaphiropoulos, PhD
John Inge Johnsen, PhD
Dr. John Inge Johnsen received his PhD diploma at University of Tromsö, Norway under the supervision of Professor Terje Traavik in 1994. His thesis focused on the characterization of regulatory genetic elements in polyomaviruses and the effects these regulatory regions have on host/virus interaction
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature