Elucidating the Somatic Epigenetic Landscape of Pediatric Meningioma and Schwannoma

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Sameer Agnihotri

UPMC Children's Hospital of Pittsburgh
Pittsburgh, PA, USA

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About this


Meningioma is the most common primary brain tumor in adults and some patients experience local recurrence. Both Meningiomas and Schwannomas are rare in the pediatric population with Schwannomas having the ability to arise from any nerve in the body. Typically, pediatric meningiomas and schwannomas are thought to be likely associated with genetic disorders such as neurofibromatosis type 2 (NF-2), Gorlin syndrome, or Rubenstein-Taybi syndrome. The molecular classification is poorly understudied in both pediatric meningiomas and pediatric schwannomas and there is an urgent need to better understand the biology of these tumors in order to find effective therapies. This research will map for the first time, the epigenome, the chemical compounds that can tell the genome what to do, of pediatric Meningiomas and Schwannomas. The comprehensive analysis of pediatric meningiomas and schwannomas may identify novel targets for therapies or predict which patients may be susceptible to local recurrence. This project can only be completed with the use of rare pediatric meningioma and schwannoma samples provided by the Children’s Brain Tumor Network.

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What are the goals of this project?

The goal of this project is to elucidate the differences between adult and pediatric forms of meningioma and schwannoma that may lead to more effective treatment strategies.

What is the impact of this project?

This project will map the epigenome of pediatric brain tumors to provide key characteristics of these tumors. The characterization will then be used to develop new therapies for pediatric patients and help understand key prognostics.

Why is the CBTN request important to this project?

Researchers need access to high quality pediatric specimens to complete this work, making the Children’s Brain Tumor Networks provisions of such samples integral.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing DNA samples.