Elucidating the Somatic Epigenetic Landscape of Pediatric Meningioma and Schwannoma
Pediatric tumors have unique properties compared to adult tumors, requiring different treatment strategies for the same tumor type. Using samples provided by the Children’s Brain Tumor Network, researchers will carry out comprehensive comparisons of pediatric meningioma and schwannoma to map these critical areas to develop novel treatments.
Cancer Predisposition in Pediatric Brain Tumors
Studies have shown that many patients with germline mutations, mutations that can be passed down, have a predisposition to central nervous system tumors. Researchers will use data from the Pediatric Brain Tumor Atlas along with patient’s clinical data and family history to study the impacts of predisposition on patient outcomes.
All Brain Tumor Types
Suzanne P. MacFarland
Scientific Reports - Nature
Harmonization of Postmortem Donations for Pediatric Brain Tumors and Molecular Characterization of Diffuse Midline Gliomas
The whole genome sequencing and RNA sequencing data related to pediatric diffuse midline gliomas that is generated by researchers on this project will be shared widely with support from CBTN.
Kambhampati M, Panditharatna E, Yadavilli S, Saoud K, Lee S, Eze A, Almira-Suarez MI, Hancock L, Bonner ER, Gittens J, Stampar M, Gaonkar K, Resnick AC, Kline C, Ho C-Y, Waanders AJ, Georgescu M-M, Rance NE, Kim Y, Johnson C, Rood BR, Kilburn LB, Hwang EI, Mueller S, Packer RJ, Bornhorst M, Nazarian J.