A common form of treatment for pediatric brain cancers is radiation therapy. Like all forms of clinical cancer intervention, there are risks, such as radiation injury. Tissues all over the body can be damaged by doses of ionizing radiation, and this is particularly true for the brain. Large doses of ionizing radiation can cause acute illness. In this study, researchers seek to determine whether germline genomic alterations correlate with patients who have experienced radiation injury. Germline genomic alterations include changes to genes in cells that are passed down in the gametes, sperm and egg. Through access to the Pediatric Brain Tumor Atlas researchers will catalog germline genomic alterations across brain cancer types in search of correlations to accounts of radiation injury. This information will be important in guiding decisions of medical professionals and reducing treatment risks to patients.
What are the goals of this project?
The goals of this project are to study germline genetic mutations in patients that have experienced radiation injury.
What is the impact of this project?
An understanding of the mutations associated with radiation injury is important for the guidance of treatment for at-risk patients.
Why is the CBTN request important to this project?
The data available through the Pediatric Brain Tumor Atlas gives researchers insight into the genome of pediatric cancer patients who have experienced radiation injury.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Sam Gadd, Bioinformatician
Ann & Robert H. Lurie Children’s Hospital of ChicagoJoined on
Ann & Robert H. Lurie Children’s Hospital of Chicago treats 220 new patients each year with pediatric cancers. The hospital is ranked 17th in the nation for their pediatric oncology program and 11th for their neurology and neurosurgery program by U.S. News & World Report.Established in 1986, the Lur