Attending Physician, Hematology, Oncology, Neuro-Oncology & Stem Cell Transplant
Ann & Robert H. Lurie Children’s Hospital of Chicago
My laboratory uses genetic mouse modeling tools to study Diffuse Intrinsic Pontine Glioma (DIPG), an incurable brain cancer that arises in children. Our three aims are to develop improved DIPG mouse models, to study the mechanism of novel oncogenes implicated in DIPG pathogenesis (e.g., H3K27M, ACVR1/ALK2), and to evaluate novel therapeutics
Genomic Correlates with Radiation Injury
This pilot project at Lurie Children's Hospital will catalog germline genomic alterations in the CBTN database (SNVs, CNVs, Indels, etc.) and see if any genetic alterations are enriched in the radiation injury group (patients that developed radiation necrosis).
Oren J. Becher
Brainstem glioma- Diffuse intrinsic pontine glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[