Identifying New Cell Surface Targets for Immunotherapy Treatment of Poor Prognosis Pediatric Brain Tumors
Email Principal Investigator
Misty Jenkins
CBTN Data
CBTN Participants
Backer
Robert Connor Dawes Foundation
Carrie's Beanies for Brain Cancer
About this
Project
Immunotherapy is a treatment strategy for patients that utilizes their own immune system to attack and remove cancer. Advancing immunotherapy requires researching the immune landscape of pediatric brain tumor patients. This will allow researchers to identify targets that are found on tumor cells and are not present on healthy cells. Once targets are identified, therapies can be developed that target the cancer cells, bolstering a patient’s immune system, leaving normal cells unharmed and hopefully leading to better outcomes. Immunotherapy has been successful in cancers of the blood but more research is needed to develop successful strategies to attack solid tumors such as those found in the brain. Researchers will screen the database of pediatric brain tumor tissue provided by the Pediatric Brain Tumor Atlas to identify a list of possibly targetable proteins. If targets specific to pediatric brain tumor types can be identified, personalized therapeutic strategies can be created for pediatric brain tumor treatments.
Ask The
Scientists
What are the goals of this project?
Researchers seek to identify targets on tumor cells that can be utilized for immunotherapy.
What is the impact of this project?
Immunotherapy has been successful in cancers of the blood, and this work could help advance its use in patients with solid tumors.
Why is the CBTN request important to this project?
The Pediatric Brain Tumor Atlas provides researchers with the broad and comprehensive data needed to complete this analysis.
Specimen Data
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Explore the data in these informatics portals
Meet The
Team
PI: Misty Jenkins, PhD - Walter and Eliza Hall Institute of Medical Research
Collaborators:
- Shiqi Stacie Wang, PhD Student, FRACP, MMedSci, MB BS - Walter and Eliza Hall Institute of Medical Research
Misty Jenkins, PhD
Our research focusses on a type of adoptive T cell immunotherapy called Chimeric Antigen Receptor T cell (CAR T cell) therapy. CAR T cells are engineered from a patient’s own T cell, to recognise and attack cancer cells. We are designing and testing CAR T cells directed against adult and paediatric
Walter and Eliza Hall Institute of Medical Research (WEHI)
Scientific Committee
Executive Board
Principal Investigator
Javad Nazarian, PhD, MSc
I am an investigator at the Center for Genetic Medicine in Children’s National Hospital in Washington, D.C., and an assistant professor in Integrative Systems Biology at the George Washington University. I received my PhD from the George Washington University in Genetics in 2005. My dissertation res
Children’s National Hospital
Melissa Davis, PhD
The Davis Laboratory studies the regulatory networks that control the behaviour of cells in normal and cancerous tissues. We approach these questions with a suite of computational techniques that include classical bioinformatics methods, knowledge-based modelling, machine learning, and network analy
Walter and Eliza Hall Institute of Medical Research (WEHI)
Stacie Wang, MSc, MBBS, FRACP
Stacie Wang currently works at the Children's Cancer Centre, The Royal Children's Hospital. Stacie is undertaking a PhD in immunotherapy and CAR-T therapy in brain tumor models. She also has an interest in fungal infection and infectious diseases in oncology. Her most recent publication is 'Towards
The Royal Children's Hospital Melbourne
Institutions
Walter and Eliza Hall Institute of Medical Research (WEHI)
WEHI is where the world’s brightest minds collaborate and innovate to make discoveries that will help us to live healthier for longer.We bring together people with different skills and experience who are committed to long-term discovery. Our medical researchers have been serving the community for mo
Primary
Children’s National Hospital
Joined onEach year, the Brain Tumor Institute at Children’s National evaluates more than 100 new patients with brain tumors, and is recognized as a world leader in childhood brain tumor care and research. Children’s National has pioneered novel pediatric brain tumor therapies, including new molecularly-targe
The Royal Children's Hospital Melbourne
The mission of The Royal Children's Hospital (RCH), in conjunction with our Campus partners, is to improve the health and well-being of children and adolescents through leadership in healthcare, research and education.The Royal Children's Hospital is co-located with Campus partners the Murdoch Child
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