Immunotherapy is a treatment strategy for patients that utilizes their own immune system to attack and remove cancer. Advancing immunotherapy requires researching the immune landscape of pediatric brain tumor patients. This will allow researchers to identify targets that are found on tumor cells and are not present on healthy cells. Once targets are identified, therapies can be developed that target the cancer cells, bolstering a patient’s immune system, leaving normal cells unharmed and hopefully leading to better outcomes. Immunotherapy has been successful in cancers of the blood but more research is needed to develop successful strategies to attack solid tumors such as those found in the brain. Researchers will screen the database of pediatric brain tumor tissue provided by the Pediatric Brain Tumor Atlas to identify a list of possibly targetable proteins. If targets specific to pediatric brain tumor types can be identified, personalized therapeutic strategies can be created for pediatric brain tumor treatments.
What are the goals of this project?
Researchers seek to identify targets on tumor cells that can be utilized for immunotherapy.
What is the impact of this project?
Immunotherapy has been successful in cancers of the blood, and this work could help advance its use in patients with solid tumors.
Why is the CBTN request important to this project?
The Pediatric Brain Tumor Atlas provides researchers with the broad and comprehensive data needed to complete this analysis.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
PI: Misty Jenkins, PhD - Walter and Eliza Hall Institute of Medical Research
- Shiqi Stacie Wang, PhD Student, FRACP, MMedSci, MB BS - Walter and Eliza Hall Institute of Medical Research
Misty Jenkins, PhD
Our research focusses on a type of adoptive T cell immunotherapy called Chimeric Antigen Receptor T cell (CAR T cell) therapy. CAR T cells are engineered from a patient’s own T cell, to recognise and attack cancer cells. We are designing and testing CAR T cells directed against adult and paediatri
Javad Nazarian, PhD, MSc
I am an investigator at the Center for Genetic Medicine in Children’s National Hospital in Washington, D.C., and an assistant professor in Integrative Systems Biology at the George Washington University. I received my PhD from the George Washington University in Genetics in 2005. My dissertation res
Children’s National Hospital
Melissa Davis, PhD
The Davis Laboratory studies the regulatory networks that control the behaviour of cells in normal and cancerous tissues. We approach these questions with a suite of computational techniques that include classical bioinformatics methods, knowledge-based modelling, machine learning, and network analy
Children’s National HospitalJoined on
Each year, the Brain Tumor Institute at Children’s National evaluates more than 100 new patients with brain tumors, and is recognized as a world leader in childhood brain tumor care and research. Children’s National has pioneered novel pediatric brain tumor therapies, including new molecularly-targe