Identifying New Cell Surface Targets for Immunotherapy Treatment of Poor Prognosis Pediatric Brain Tumors

Email Principal Investigator
Ongoing
Data
Avoiding Immune Destruction
Target Identification
All Brain Tumor Types
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Misty Jenkins

Walter and Eliza Hall Institute of Medical Research (WEHI)
1G Royal Parade, Parkville Victoria 3052, Australia

CBTN Data

966

CBTN Participants

Backer

Robert Connor Dawes Foundation

Carrie's Beanies for Brain Cancer

About this

Project

Immunotherapy is a treatment strategy for patients that utilizes their own immune system to attack and remove cancer. Advancing immunotherapy requires researching the immune landscape of pediatric brain tumor patients. This will allow researchers to identify targets that are found on tumor cells and are not present on healthy cells. Once targets are identified, therapies can be developed that target the cancer cells, bolstering a patient’s immune system, leaving normal cells unharmed and hopefully leading to better outcomes. Immunotherapy has been successful in cancers of the blood but more research is needed to develop successful strategies to attack solid tumors such as those found in the brain. Researchers will screen the database of pediatric brain tumor tissue provided by the Pediatric Brain Tumor Atlas to identify a list of possibly targetable proteins. If targets specific to pediatric brain tumor types can be identified, personalized therapeutic strategies can be created for pediatric brain tumor treatments.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Researchers seek to identify targets on tumor cells that can be utilized for immunotherapy.

What is the impact of this project?

Immunotherapy has been successful in cancers of the blood, and this work could help advance its use in patients with solid tumors.

Why is the CBTN request important to this project?

The Pediatric Brain Tumor Atlas provides researchers with the broad and comprehensive data needed to complete this analysis.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals

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Meet The

Team

PI: Misty Jenkins, PhD - Walter and Eliza Hall Institute of Medical Research

Collaborators:

  • Shiqi Stacie Wang, PhD Student, FRACP, MMedSci, MB BS - Walter and Eliza Hall Institute of Medical Research
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Misty Jenkins, PhD

Our research focusses on a type of adoptive T cell immunotherapy called Chimeric Antigen Receptor T cell (CAR T cell) therapy.  CAR T cells are engineered from a patient’s own T cell, to recognise and attack cancer cells. We are designing and testing CAR T cells directed against adult and paediatric

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Walter and Eliza Hall Institute of Medical Research (WEHI)

1G Royal Parade, Parkville Victoria 3052, Australia
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Scientific Committee

Executive Board

Principal Investigator

Javad Nazarian, PhD, MSc

I am an investigator at the Center for Genetic Medicine in Children’s National Hospital in Washington, D.C., and an assistant professor in Integrative Systems Biology at the George Washington University. I received my PhD from the George Washington University in Genetics in 2005. My dissertation res

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Children’s National Hospital

Washington, DC, USA
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Melissa Davis, PhD

The Davis Laboratory studies the regulatory networks that control the behaviour of cells in normal and cancerous tissues. We approach these questions with a suite of computational techniques that include classical bioinformatics methods, knowledge-based modelling, machine learning, and network analy

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Walter and Eliza Hall Institute of Medical Research (WEHI)

1G Royal Parade, Parkville Victoria 3052, Australia
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Stacie Wang, MSc, MBBS, FRACP

Stacie Wang currently works at the Children's Cancer Centre, The Royal Children's Hospital. Stacie is undertaking a PhD in immunotherapy and CAR-T therapy in brain tumor models. She also has an interest in fungal infection and infectious diseases in oncology. Her most recent publication is 'Towards

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The Royal Children's Hospital Melbourne

50 Flemington Road Parkville Victoria 3052 Australia

related

Histologies