The Walter and Eliza Hall Institute of Medical Research
The Davis Laboratory studies the regulatory networks that control the behaviour of cells in normal and cancerous tissues. We approach these questions with a suite of computational techniques that include classical bioinformatics methods, knowledge-based modelling, machine learning, and network analysis.
Our current focus is understanding the signalling and regulatory networks that underpin epithelial-mesenchymal transitions in breast cancer. Our work in this space is part of the EMPathy Breast Cancer Network, and is funded by the National Breast Cancer Foundation.
Identifying New Cell Surface Targets for Immunotherapy Treatment of Poor Prognosis Pediatric Brain Tumors
Immunotherapy is a treatment strategy for patients that utilizes their own immune system to attack and remove cancer, and more research is needed to utilize such therapies for the treatment of pediatric brain cancers. Researchers will screen data provided by the Pediatric Brain Tumor Atlas in an effort to identify possible immunotherapy targets.
All Brain Tumor Types
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with