The Walter and Eliza Hall Institute of Medical Research
Our research focusses on a type of adoptive T cell immunotherapy called Chimeric Antigen Receptor T cell (CAR T cell) therapy. CAR T cells are engineered from a patient’s own T cell, to recognise and attack cancer cells. We are designing and testing CAR T cells directed against adult and paediatric brain tumours. We are also investigating how to best activate T cells to allow for tailored immune responses to solid tumours.
Identifying New Cell Surface Targets for Immunotherapy Treatment of Poor Prognosis Pediatric Brain Tumors
Immunotherapy is a treatment strategy for patients that utilizes their own immune system to attack and remove cancer, and more research is needed to utilize such therapies for the treatment of pediatric brain cancers. Researchers will screen data provided by the Pediatric Brain Tumor Atlas in an effort to identify possible immunotherapy targets.
All Brain Tumor Types
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with