Mechanistic Modeling of high grade glioma

Ongoing
Data
HGG
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CBTN Data Used

Backer

iPC Horizon2020 EU project

About this

Project

We are part of the EU funded project “individualized paediatric cure- iPC” (https://ipc-project.eu/) that aims to find novel therapeutic routes for children with cancer based on systems biological analysis and modeling of large scale genomic, transcriptomic and proteomic data sets. High grade glioma patients from the open-PBTA dataset would strongly benefit from such analysis. For this project, we want to model in-silico drug responses of an initial cohort of ~20 patients with our mechanistic ModCell model. This will take into account the SNVs/Indels, copy number losses and gene fusions, essentially based on the available processed data.

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Scientists

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What are the goals of this project?

We will use a computer model to find potential drug treatments for high grade glioma patients.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals

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