Molecular Analysis of the Cellular Ecosystem of Childhood Ependymoma
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About this
Project
For pediatric brain cancer patients younger than 3 years old, ependymomas are one of the most common forms of central nervous system growth. With no effective chemotherapy currently available to treat ependymomas, there is a less than 55% 5-year survival rate in young patients. Researchers are seeking to build up the knowledge base around ependymomas and the mechanisms of their growth using RNA sequencing available through the Pediatric Brain Tumor Atlas. Greater understanding of ependymoma growth will guide the therapeutic decisions of medical professionals.
Ask The
Scientists
What are the goals of this project?
Researchers are pursuing a deeper understanding of ependymoma growth and identifying possible targets for immunotherapy.
What is the impact of this project?
Ependymoma presents a huge challenge in finding effective treatment options. This project will provide comprehensive information necessary to find new therapies.
Why is the CBTN request important to this project?
Accessing the Pediatric Brain Tumor Atlas, researchers will be able to further explore and validate preliminary results of this large study.
Specimen Data
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Meet The
Team
Dr. Wu (snRNA-seq) and Dr. Nasrallah (histopathology) at the University of Pennsylvania, and Dr. Santi (histopathology) at the Children´s Hospital of Philadelphia
Institutions
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Histologies
Ependymoma
Ependymoma
Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors
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