Molecular Analysis of the Cellular Ecosystem of Childhood Ependymoma

Email Principal Investigator
Tumor Microenvironment
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Pablo G. Cámara

University of Pennsylvania
Philadelphia, PA, USA


About this


For pediatric brain cancer patients younger than 3 years old, ependymomas are one of the most common forms of central nervous system growth. With no effective chemotherapy currently available to treat ependymomas, there is a less than 55% 5-year survival rate in young patients. Researchers are seeking to build up the knowledge base around ependymomas and the mechanisms of their growth using RNA sequencing available through the Pediatric Brain Tumor Atlas. Greater understanding of ependymoma growth will guide the therapeutic decisions of medical professionals.

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What are the goals of this project?

Researchers are pursuing a deeper understanding of ependymoma growth and identifying possible targets for immunotherapy.

What is the impact of this project?

Ependymoma presents a huge challenge in finding effective treatment options. This project will provide comprehensive information necessary to find new therapies.

Why is the CBTN request important to this project?

Accessing the Pediatric Brain Tumor Atlas, researchers will be able to further explore and validate preliminary results of this large study.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.