For this project, tumors of the specific diagnoses of neurocytoma were identified for whole-genome and RNA sequencing. Whole genome sequencing involves identifying all of the base chemicals that make up the DNA in a genome. RNA sequencing involves analyzing for the presence and quantity of RNA. Both of these analyses are integral in the field of cancer biology and cancer treatment because they help researchers better understand how a tumor forms, grows, and persists. The goal of this project is to perform whole genome and RNA sequencing on neurocytomas. The Children's Brain Tumor Network contributed to the project by providing germline and tumor DNA and tumor RNA for use by investigators. The information gained from this work could lead to advances in treatment for patients with neurocytoma.
What are the goals of this project?
Researchers will conduct RNA and whole genome sequencing on neurocytoma samples in an effort to better understand their formation and persistence.
What is the impact of this project?
This project will fill a knowledge gap about neurocytoma and could lead to advancements in treatment for this disease. The data generated will be shared will all researchers.
Why is the CBTN request important to this project?
Quality specimens are hard to come by in the field of pediatric brain cancers, but the Children’s Brain Tumor Network provides researchers with quality neurocytoma specimens with which they can complete this work.
The Children's Brain Tumor Network contributed to the project by providing germline and tumor DNA and tumor RNA.
Adam Resnick, PhD
Adam Resnick is the Director of Data Driven Discovery in Biomedicine (D3b) at Children’s Hospital of Philadelphia (CHOP) responsible for leading a multidisciplinary team to build and support a scalable, patient-focused healthcare and educational discovery ecosystem on behalf of all children. He is a
Children’s Hospital of Philadelphia
Angela Waanders, MD, MPH
Specialties:Hematology, Oncology, Neuro-Oncology & Stem Cell TransplantationEducation: Tulane University School of Medicine, 2003Postgraduate Training: Fellowship in pediatric hematology/oncology, Children's Hospital of Philadelphia, 2006-2009; Residency is pediatrics, Children's Hospital of Philade
Ann & Robert H. Lurie Children’s Hospital of Chicago
Children’s Hospital of PhiladelphiaJoined on
Operations Center for the Children’s Brain Tumor Tissue Consortium, the Children’s Hospital of Philadelphia (CHOP) is currently ranked 1st nationally for their Pediatric Cancer Program by U.S. News & World Report. CHOP’s Biobank is home to the CBTTC’s pediatric brain and CNS tumor biorepository; the
Ann & Robert H. Lurie Children’s Hospital of ChicagoJoined on
Ann & Robert H. Lurie Children’s Hospital of Chicago treats 220 new patients each year with pediatric cancers. The hospital is ranked 17th in the nation for their pediatric oncology program and 11th for their neurology and neurosurgery program by U.S. News & World Report.Established in 1986, the Lur
Cancer Informatics for Cancer Centers (CI4CC)
Innovation Through Collaboration: Emerging Models in Pediatric for Data Driven Healthcare Ecosystem
Adam Resnick and Allison Heath