Angela Waanders

MD, MPH
Scientific Committee
Executive Board
Executive co-Chair
Principal Investigator

Chicago, IL 60611, USA

Ann & Robert H. Lurie Children’s Hospital of Chicago

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About

Director, Precision Medicine Oncology; Program Director, Pediatric Neuro-Oncology Fellowship; Executive Board Chair, Children's Brain Tumor Network

Ann & Robert H. Lurie Children’s Hospital of Chicago

Specialties:

Education: Tulane University School of Medicine, 2003

Postgraduate Training: Fellowship in pediatric hematology/oncology, Children's Hospital of Philadelphia, 2006-2009; Residency is pediatrics, Children's Hospital of Philadelphia, 2003-2006

Board Certifications: Pediatrics, Pediatric Hematology-Oncology

See Northwestern University Faculty Profile >

Sievert AJ, Jackson EM, Gai X, Hakonarson H, Judkins AR, Resnick AC, Sutton LN, Storm PB, Shaikh TH, Biegel JA. Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single –nucleotide polymoprhism-based genotype arrays results in a novel BRAF fusion gene. Brain Pathology 2009 Jul; 19 (3):449-58. Epub 2008 Oct 21. PMID: 19016743

Jackson EM, Sievert AJ, Gai X, Hakonarson H, Judkins AR, Tooke L, Perin JC, Xie H, Shaikh TH, Biegel JA. Genomic Analysis Using High-Density Single Nucleotide Polymorphism-Based Oligonucleotide Arrays and Multiplex Ligation-Dependent Probe Amplification Provides a Comprehensive Analysis of INI1/SMARCB1 in Malignant Rhabdoid Tumors. Clinical Cancer Research March 15, 2009; 15 (6):1923.1930. Epub 2009 Mar 10. PMID: 19276269

Dougherty MJ, Santi M, Brose MS, Ma C, Resnick AC, Sievert AJ, Storm PB, Biegel JA. Activating mutations in BRAF characterize a spectrum of low-grade gliomas. Neuro Oncology 2010 Jul; 12 (7): 621-30. Epub 2010 Feb 14. PMID: 20156809

Stephens, J, Sievert AJ, Judkins AR, Resnick AC, Storm PB, Rushing E, Santi M. Spinal cord ependymomas and myxopapillary ependymomas in the first two decades of life: a clinicopathological and immunohistochemical characterization of 19 cases. J of Neurosurg Pediatr. 2012 Jun; 9 (6):646-53. PMID: 22656257

Sievert AJ, Lang SS, Boucher KL, Madsen PJ, Slaunwhite E, Choudhari N, Kellet M, Storm PB, and Resnick AC. Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. PNAS 2013 April; 110 (15): 5957-5962. Epub 2013 Mar 26. PMID: 23533272

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Ann & Robert H. Lurie Children’s Hospital of Chicago

Chicago, Illinois, USA

scientific

Projects

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Specimen

Completed

Neurocytoma WGS and RNAseq

The effective treatment of brain tumors requires a robust understanding of their biology. Using rare, high quality neurocytoma samples provided by the Children’s Brain Tumor Network, researchers seek to develop new treatments for this disease.

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Adam Resnick

Children’s Hospital of Philadelphia
Philadelphia, PA, USA
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Data

Ongoing

Characterizing the Prevalence of ETMR by Molecular Signature

Embryonal tumors with multilayer rosettes (ETMR) have recently been reclassified and clinical investigations are needed to understand their occurrence and prevalence. ETMR specimens from the Pediatric Brain Tumor Atlas will be used by researchers to begin building a robust understanding and characterization of the tumor.

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Derek Hanson

Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center
Hackensack, NJ, USA
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Data

Ongoing

Health Disparities of Pediatric Brain Tumors

Data points to disparities of cancer diagnosis and outcomes across children in different racial and ethnic groups. In an effort to better understand these disparities, researchers will interrogate data provided by the Pediatric Brain Tumor Atlas.

Medulloblastoma, HGG, Ependymoma

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Xiao-Nan Li

Ann & Robert H. Lurie Children’s Hospital of Chicago
Chicago, Illinois, USA
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Specimen

Completed

Whole Genome Sequencing and RNA Sequencing of the CBTN Bank for the Pediatric Brain Tumor Atlas

Research into adult cancer has benefited greatly from large scale genomic research. Until now due to the limited resources and availability pediatric brain tumors have not been part of large-scale genomic generation efforts. The CBTN aims to create a comprehensive genomic atlas for use by researchers worldwide to unlock how brain tumors develop, grow, survive, and how they can be treated and cured.

Craniopharyngioma, Medulloblastoma, HGG, (AT/RT), LGG, Ependymoma, Ganglioglioma, DNET, Choroid Plexus Tumors, Meningioma, DIPG, Oligodendroglioma, Schwannoma, Germinoma, Choroid Plexus Tumors, Subependymal Giant cell Astrocytoma, NGGCTs

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Adam Resnick

Children’s Hospital of Philadelphia
Philadelphia, PA, USA
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Specimen

Completed

Target Identification and Modeling of NF1-associated Low-grade Glioma

Low grade gliomas are often associated with the genetic disorder neurofibromatosis type 1 and research is needed to develop targeted therapies for such tumors. The Children’s Brain Tumor Network is providing researchers with rare samples necessary to accelerate progress in the treatment of NF1-LGGs.

LGG

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Michael J. Fisher

Children’s Hospital of Philadelphia
Philadelphia, PA, USA
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Data

Ongoing

Cancer Predisposition in Pediatric Brain Tumors

Studies have shown that many patients with germline mutations, mutations that can be passed down, have a predisposition to central nervous system tumors. Researchers will use data from the Pediatric Brain Tumor Atlas along with patient’s clinical data and family history to study the impacts of predisposition on patient outcomes.

All Brain Tumor Types

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Suzanne P. MacFarland

Children’s Hospital of Philadelphia
Philadelphia, PA, USA
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Data

Ongoing

Descriptive "Pharmacogenomics Analysis" of the CBTN PBTA Cohort

Many pediatric brain cancer patients experience toxicities related to the use of vincristine in treatment protocols. Using the Pediatric Brain Tumor Atlas, this study will help to define the frequency of genetic risks for side effects in an effort to lessen the need for treatment reductions.

All Brain Tumor Types

Angela Waanders.jpg

Angela Waanders

Ann & Robert H. Lurie Children’s Hospital of Chicago
Chicago, Illinois, USA

related

Publications

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