Whole Genome Sequencing and RNA Sequencing of the CBTN Bank for the Pediatric Brain Tumor Atlas

Email Principal Investigator
Completed
Specimen
Tumor Subtyping
Target Identification
Craniopharyngioma
Medulloblastoma
HGG
(AT/RT)
LGG
Ependymoma
Ganglioglioma
DNET
Choroid plexus tumors
Meningioma
DIPG
Oligodendroglioma
Schwannoma
Germinoma
Choroid Plexus Tumors
Subependymal Giant cell Astrocytoma
NGGCTs

Supratentorial or Spinal Cord PNET

Hemangioblastoma

Ganglioneuroblastoma

Dysplasia/Gliosis

Neurofibroma/Plexiform

Langerhans Cell histiocytosis

Teratoma

Ewing's Sarcoma

Neuroblastoma

Gliomatosis Cerebri

Chordoma

Cavernoma

Malignant peripheral nerve sheath tumor (MPNST)

Sarcoma

Adenoma

Pineoblastoma

Neurocytoma

Rhabdomyosarcoma

Asset 20.png
ewc_CHOPFoundation(1)01201604184.jpg

Adam Resnick

Children’s Hospital of Philadelphia
Philadelphia, PA, USA

CBTN Specimen

1130

CBTN Participants

Backer

NantOmics

Completed

About this

Project

Information about the genetic underpinnings of pediatric brain cancers is necessary for tumor identification, testing, and treatment. In an effort to expand genetic understanding, The Children’s Brain Tumor Network collection of biospecimens approximately 1650 subsamples from the CBTN BioBank have undergone Whole Genome Sequencing and RNA sequencing. This is the largest collection of such data for pediatric brain tumors and the information is open access through the Pediatric Brain Tumor Atlas, allowing researchers from all over the world a chance to further analyze..

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Researchers will expand the understanding of pediatric brain tumors through comprehensive genetic analysis of the CBTN sample bank

What is the impact of this project?

Open access data of pediatric brain cancers is crucial in finding new therapies as quickly as possible. All data from this project will be available to researchers around the world, further supporting CBTN’s vision of collaboration for accelerated discoveries and improved treatments.

Why is the CBTN request important to this project?

Whole Genome Sequencing and RNA sequencing of a large majority of CBTN samples will result in the largest open access collection of such data for pediatric brain cancers. Providing researchers for the first time the data required to identify new treatments.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing tumor and germline DNA and tumor RNA.

Meet The

Team

ewc_CHOPFoundation(1)01201604184.jpg

Scientific Committee

Executive Board

Scientific co-Chair

Principal Investigator

Adam Resnick, PhD

Adam Resnick is the Director of Data Driven Discovery in Biomedicine (D3b) at Children’s Hospital of Philadelphia (CHOP) responsible for leading a multidisciplinary team to build and support a scalable, patient-focused healthcare and educational discovery ecosystem on behalf of all children. He is a

CHOP.jpg

Children’s Hospital of Philadelphia

Philadelphia, PA, USA
Angela Waanders.jpg

Scientific Committee

Executive Board

Executive co-Chair

Principal Investigator

Angela Waanders, MD, MPH

Specialties:Hematology, Oncology, Neuro-Oncology & Stem Cell TransplantationEducation: Tulane University School of Medicine, 2003Postgraduate Training: Fellowship in pediatric hematology/oncology, Children's Hospital of Philadelphia, 2006-2009; Residency is pediatrics, Children's Hospital of Philade

Ann_&_Robert_H._Lurie_Children's_Hospital_of_Chicago.jpg

Ann & Robert H. Lurie Children’s Hospital of Chicago

Chicago, Illinois, USA
Javad Nazarian PhD.jpg

Scientific Committee

Executive Board

Principal Investigator

Javad Nazarian, PhD, MSc

I am an investigator at the Center for Genetic Medicine in Children’s National Hospital in Washington, D.C., and an assistant professor in Integrative Systems Biology at the George Washington University. I received my PhD from the George Washington University in Genetics in 2005. My dissertation res

CNHS.jpg

Children’s National Hospital

Washington, DC, USA
rishi_lulla.original.jpg

Rishi Ramesh Lulla, MD

pediatric brain, central nervous system,  and spinal cord tumors

BrownUniversityMedSchool.jpg

The Warren Alpert Medical School of Brown University

Providence, RI
Phillip_Storm-260x312.original.jpg

Scientific Committee

Executive Board

Principal Investigator

Phillip Jay Storm, MD

I am chief of the Division of Neurosurgery at The Children’s Hospital of Philadelphia and an attending neurosurgeon specializing in pediatric brain tumors. I operate on every type of brain tumor, but I have a particular interest in low-grade gliomas, medulloblastomas and atypical teratoid rhabdoid t

CHOP.jpg

Children’s Hospital of Philadelphia

Philadelphia, PA, USA
Mason.jpg

Operations Center

Jennifer Mason, BA

Jennifer Mason is responsible for the overall project and operations management for multiple projects under the CTU division of the D3b Center at the Children's Hospital of Philadelphia, including the Children’s Brain Tumor Network (CBTN), and autopsy projects. She is also responsible for ensuring d

CHOP.jpg

Children’s Hospital of Philadelphia

Philadelphia, PA, USA
Elizabeth_Appert.jpg

Elizabeth Appert, MS

CHOP.jpg

Children’s Hospital of Philadelphia

Philadelphia, PA, USA
Jena_Lilly.jpg

Executive Board

Jena Lilly, MS, CCRC

Jena Lilly is the Director of Operations and Strategic Planning for the Center for Data Driven Discovery in Biomedicine. Currently, she leads a team of over 30 people in support of international pediatric oncology research consortiums which combined, include over 25 pediatric hospitals. She is also

CHOP.jpg

Children’s Hospital of Philadelphia

Philadelphia, PA, USA

related

Histologies

Craniopharyngioma.png

Craniopharyngioma

Childhood craniopharyngiomas are rare tumors usually found near the pituitary gland (a pea-sized organ at the bottom of the brain that controls other glands) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).Craniopharyngiomas are usually part solid mass and

129
Participants
6
Projects Supported
Medulloblastoma.png

Medulloblastoma

Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature

443
Participants
35
Projects Supported
High-grade glioma_astrocytoma (WHO grade III_IV).png

High-Grade Glioma

High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test

348
Participants
61
Projects Supported
ATRT.png

Atypical Teratoid/Rhabdoid Tumor

Central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT) is a very rare, fast-growing tumor of the brain and spinal cord. It usually occurs in children aged three years and younger, although it can occur in older children and adults. About half of these tumors form in the cerebellum or

100
Participants
13
Projects Supported
Low-grade astrocymas.png

Low-Grade Glioma

Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su

1003
Participants
23
Projects Supported
Ependymoma.png

Ependymoma

Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors

319
Participants
22
Projects Supported
Ganglioma.png

Ganglioglioma

Ganglioglioma presents during childhood and into adulthood. It most commonly arises in the cerebral cortex and is associated with seizures, but also presents in other sites, including the spinal cord.[65,74]The unifying theme for the molecular pathogenesis of ganglioglioma is genomic alterations lea

185
Participants
7
Projects Supported
Dysembryoplastic neuroepithelial tumor (DNET).png

Dysembryoplastic Neuroepithelial Tumor

Septal DNET generally presents with symptoms related to obstructive hydrocephalus.[69,70] Septal DNET has an indolent clinical behavior, with most tumors not requiring treatment other than surgery. In a single-institution series that incorporated other literature-reported cases, the median age at pr

76
Participants
6
Projects Supported
Choroid Plexus Papilloma.png

Choroid Plexus Papilloma

Choroid plexus tumors are primary central nervous system (CNS) tumors. This means they begin in the brain or spinal cord.Choroid plexus papillomas are grouped in two grades based on their characteristics.Grade I choroid plexus papilloma are low grade tumors. This means the tumor cells grow slowly.Gr

69
Participants
2
Projects Supported
Meningioma.png

Meningioma

A meningioma is a primary central nervous system (CNS) tumor. This means it begins in the brain or spinal cord. Overall, meningiomas are the most common type of primary brain tumor.  However, higher grade meningiomas are very rare. 

83
Participants
5
Projects Supported
Brainstem Glioma.png

Diffuse Intrinsic Pontine Glioma

A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[5] New approaches with

136
Participants
30
Projects Supported
Oligodendroglioma.png

Oligodendroglioma

Oligodendroglioma is a primary central nervous system (CNS) tumor. This means it begins in the brain or spinal cord.Oligodendrogliomas are grouped in two grades based on their characteristics.Grade II oligodendrogliomas are low grade tumors. This means the tumor cells grow slowly and invade nearby n

27
Participants
3
Projects Supported
Schwannoma.png

Schwannoma

Schwannoma is a rare type of tumor that forms in the nervous system. Schwannoma grows from cells called Schwann cells. Schwann cells protect and support the nerve cells of the nervous system. Schwannoma tumors are often benign, which means they are not cancer. But, in rare cases, they can become can

54
Participants
6
Projects Supported
Germinoma.png

Germinoma

Germinomas are the most common type of CNS germ cell tumor and have a good prognosis.Germ cells are special types of cells that are present as the fetus (unborn baby) develops. These cells usually become sperm in the testicles or unfertilized eggs in the ovaries as the child matures. Most germ cell

46
Participants
3
Projects Supported
Choroid Plexus Carcinoma.png

Choroid Plexus Carcinoma

Choroid plexus tumors (Grade III) occur in both children and adults, but are more common in children in the first year of life. Choroid plexus tumors occur slightly more often in females than males.The cause of most choroid plexus tumors is not known. Genetic changes have been linked to the formatio

24
Participants
3
Projects Supported
Subependymal Giant cell Astrocytoma.png

Subependymal Giant cell Astrocytoma

A benign (not cancer), slow-growing tumor that usually forms in the walls of fluid-filled spaces in the brain. The tumors are made up of large, star-shaped cells called astrocytes. Subependymal giant cell astrocytomas are common in patients with tuberous sclerosis (an inherited disorder in which ben

8
Participants
1
Projects Supported
Asset 28.png

Nongerminomatous Germ Cell Tumors

Primary CNS GCTs are a heterogeneous group of neoplasms that are more common in Japan and other Asian countries than in North America and Europe. In North America, they account for approximately 4% of all primary brain tumors, with a peak incidence from age 10 years to age 19 years and a male predom

7
Participants
3
Projects Supported